FOOD SCIENCE ›› 2021, Vol. 42 ›› Issue (13): 127-135.doi: 10.7506/spkx1002-6630-20201013-119

• Nutrition & Hygiene • Previous Articles     Next Articles

Effect of Ginseng Water-Soluble Dietary Fiber on Glucolipid Metabolism, Oxidative Stress and Intestinal Health in Rats

HUA Mei, FAN Meiling, LI Zhiman, DONG Lina, LI Shanshan, SUN Yinshi   

  1. (1. Institute of Special Animals and Plants, Chinese Academy of Agricultural Sciences, Changchun 130112, China; 2. Jilin Academy of Chinese Medicine Sciences, Changchun 130021, China)
  • Online:2021-07-15 Published:2021-07-27

Abstract: Purpose: To investigate the effect of ginseng water-soluble dietary fiber (GSDF) on glucolipid metabolism and intestinal health in rats. Methods: SD rats were gavaged with GSDF or an equal volume of normal saline as a control for 15 days, and they were evaluated for growth performance, metabolism level and intestinal flora structure. Results: GSDF could significantly increase the feed intake of rats (P < 0.01), but had no significant effect on percent body mass gain, feed utilization rate or visceral organ indexes (P > 0.05). Low-dose GSDF significantly increased fasting insulin level (P < 0.05), and decreased total cholesterol level (P < 0.05). High-dose GSDF significantly reduced fasting blood glucose (P < 0.05) and total triglyceride level (P < 0.01). GSDF significantly reduced serum malondialdehyde content (P < 0.01), and improved total antioxidant capacity (P < 0.01). Low-dose GSDF significantly reduced the inflammatory factor levels including tumor necrosis factor α (P < 0.01), interleukin (IL) 1β (P < 0.05) and IL-4 (P < 0.01), and increased fecal water content (P < 0.05). Moreover, GSDF increased the abundance of intestinal Firmicutes and Lactobacillus, changing the structure of intestinal flora in the direction of enriching probiotics and cellulose-degrading bacteria, and affected the functional gene expression of related metabolic pathways. Conclusion: GSDF exerts a positive effect on rats by regulating growth metabolism, oxidative stress status and intestinal flora structure.

Key words: ginseng water-soluble dietary fiber; growth performance; glycolipid metabolism; oxidative stress; intestinal health

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