Alleviating Effect and Mechanism of Casein Glycomacropeptide on Colitis in Rats

doi:10.7506/spkx1002-6630-20250306-049

Abstract

Abstract: In this study, a rat model of ulcerative colitis (UC) induced by sodium dextran sulfate (DSS) was used to investigate the ameliorative effect of casein glycomacropeptide (CGMP) on colitis. The results showed that CGMP improved the growth performance and reduced the disease activity index (DAI) of UC rats. Mechanistic studies revealed that CGMP improved intestinal permeability by reducing the degree of inflammatory infiltration in the colon tissue and the levels of the inflammatory factors TNF-α and IL-6, thereby alleviating colon tissue damage caused by DSS. At the same time, it protected the intestinal mucosal barrier and alleviated the symptoms of enteritis by regulating the production of short-chain fatty acids by the intestinal flora.

Key words: casein glycomacropeptide; ulcerative colitis; mechanical barrier; immune barrier; biological barrier; chemical barrier

CLC Number:

TS201.4

LIU Qi, ZHAO Yuqing, CHEN Siyang, HAN Xiaoqian, HAN Feifei. Alleviating Effect and Mechanism of Casein Glycomacropeptide on Colitis in Rats[J]. FOOD SCIENCE, 2025, 46(15): 205-201.

[1]	SUN Yang, XU Chenfeng, CHENG Kaixuan, KANG Yu, LIU Bowen, ZHANG Chi, CHEN Shuai, SHANG Longchen. Effects of Texture Properties of Konjac Glucomannan Gel on Starch Digestion and Appetite [J]. FOOD SCIENCE, 2025, 46(15): 76-83.
[2]	ZHANG Jing, LIANG Qimeng, SONG Xiaodong, JIN Junhua, XIE Yuanhong, ZHANG Hongxing. Comparative Analysis of the Effects of Bifidobacterium animalis J12 and Its Postbiotics on Cyclophosphamide-Induced Immune System Imbalance [J]. FOOD SCIENCE, 2025, 46(15): 174-170.
[3]	LI Huaxiang, LIU Qian, WU Shuqian, DAI Jianing, YE Qingya, JI Dan, XIAO Yujuan, LIU Nan, YANG Zhenquan. Triterpenoid from Antrodia cinnamomea Ameliorates Reserpine-Induced Depressive-like Behaviors and Gut Microbiota Imbalance in Mice [J]. FOOD SCIENCE, 2025, 46(15): 184-180.
[4]	KOU Rongwei, YANG Xinyi, HE Yangqing, XIA Bing, LIU Junchao, ZHAO Beita, LIU Xuebo. Evaluation of Antidepressant Compounds in Ganoderma lucidum Using Network Pharmacology [J]. FOOD SCIENCE, 2025, 46(15): 194-190.
[5]	HAN Liguang, LIANG Wanxia, WANG Wenshuo, XIAO Jie, HO Chi-Tang, Lü Muwen. Regulatory Effect and Mechanism of Capsaicin on the Circadian Rhythm of Hepatic and Pancreatic Glucose Metabolism in High-Fructose and High-Fat Diet-Fed Mice [J]. FOOD SCIENCE, 2025, 46(15): 212-212.
[6]	REN Xiaomin, QIN Mingzhen, ZHANG Shaolong, ZHANG Fan, YAN Fen. Alginate Oligosaccharides Regulate Gut Microbiota Homeostasis and Short-Chain Fatty Acid Metabolism, and Ameliorate Inflammatory Bowel Disease [J]. FOOD SCIENCE, 2025, 46(15): 224-219.
[7]	LIN Yao, PENG Yu, HAN Qiuyu, JIANG Yuanxue, ZHAO Jing. Advances in Understanding the Nutritional Value and Digestive Characteristics of Plant-Based Meat [J]. FOOD SCIENCE, 2025, 46(15): 357-338.
[8]	ZHAO Ziqi, ZHANG Qianyi, XU Jiao, GUO Xiaohui. Alleviating Effect and Mechanism of Ginsenosides on Type 2 Diabetic Liver Lesions [J]. FOOD SCIENCE, 2025, 46(15): 393-424.
[9]	YAN Heng, CHEN Yan, MEI Xinyao, WANG Xutang, FENG Fengqin, CAI Haiying, ZHAO Minjie. Promoting Effect and Mechanism of Glycerol Monolaurate on Bone Growth in Growing Rats [J]. FOOD SCIENCE, 2025, 46(14): 147-147.
[10]	JING Zhaoxuan, LIANG Peixin, HAN Xuemei, ZHANG Yihua, DENG Langni, JIA Longgang, WANG Yanping, GENG Weitao. Lactiplantibacillus plantarum IOB602 Postbiotic Ameliorates Depression-like Behaviors by Regulating Neuroendocrine Factors and Gut Microbiota in Mice [J]. FOOD SCIENCE, 2025, 46(14): 168-162.
[11]	LI Xianxiu, HE Tao, MAO Yangchen, MAO Jianwei, LAI Xiaojin, SHAO Yihuai, SHA Ruyi. Protective Effect and Mechanism of Edible Grass (Rumex patientia L. × Rumex tianschanicus A.LOS) Jiaosu on Alcohol-Induced Injury in HepG2 Cells [J]. FOOD SCIENCE, 2025, 46(14): 179-170.
[12]	MA Yutong, JIAO Yingshuai, LIU Shuyu, WU Junjie, YU Wenlong, WANG Xianghong. Effect of Sulforaphane on Colon Cancer Cell Invasion and Metastasis [J]. FOOD SCIENCE, 2025, 46(14): 187-180.
[13]	WANG Chunhua, XIAO Ying, SUN Bin, PAN Liang, LIU Jieying, JIANG Yongying, ZHOU Yiming, YE Lin, LIU Xiaojie. Effect of Coffee Extracts with Different Roasting Degrees on Lipid Metabolism and Gut Microbiota in High-Fat Fed Mice [J]. FOOD SCIENCE, 2025, 46(14): 197-190.
[14]	LIN Lulu, ZHENG Liping, MENG Ganlu, LIU Wenying, CHEN Liang, ZHANG Xinxue. Research Progress on the Preparation, Structural Analysis and Physiological Functions of Glutamine Peptides [J]. FOOD SCIENCE, 2025, 46(14): 387-396.
[15]	Yuan-Yang NIE Li -Bo. Mechanism of the auxiliary hypolipidemic function of Flammulina velutipes fermented by lactic acid bacteria through regulating the interaction between gut microbiota and host metabolism [J]. FOOD SCIENCE, 0, (): 0-0.

Alleviating Effect and Mechanism of Casein Glycomacropeptide on Colitis in Rats

RichHTML

PDF (PC)

Knowledge

Abstract

Cite this article

share this article

References

Related Articles 15

Recommended Articles

Metrics

Comments