Abstract:

Objective: To study the hypoglycemic effect of water extract from Hubei Rubus chingii Hu leaves in alloxan-induced diabetic mice and adults with high blood sugar. Methods: In animal trails, diabetic mice induced by tail vein injection of alloxan were administered water extract from Hubei R. chingii Hu leaves at doses of 0.40, 0.80 g/kg bw and 1.20 g/kg bw for 30 consecutive days. Fasting blood sugar and post-glucose blood sugar in mice were measured. In human trials, 106 patients with type II diabetes were recruited and randomly divided into two groups, namely experimental and control groups. The experiment group was administered capsules made of water extract from Hubei R. chingii Hu leaves for 30 consecutive days, while the control group was given placebo. Fasting blood sugar and 2 h post-meal blood sugar were measured. Blood biochemical index, liver function and kidney function were measured to evaluate the safety of water extract from Hubei R. chingii Hu leaves. Results: In animal trials, compared with the control group, fasting blood sugar of mice administered the water extract at doses of 0.80 g/kg bw and 1.20 g/kg bw exhibited a significant decrease. In human trials, diabetic symptoms in the experimental group were significantly attenuated. Compared to the pre-administration experimental group, fasting blood sugar and 2 h post-meal blood sugar in the post-administration experimental group revealed the reductions of 16.9% and 16.0%, respectively. Meanwhile, there were extremely significant differences between the post-administration experimental group and pre-administration one or the control group. Conclusion: Water extract from Hubei R. chingii Hu leaves has an obvious hypoglycemic effect in diabetic mice and human adults with high blood sugar.

Key words: R. chingii Hu leaf, health food, blood sugar, animal experiment, adults experiment