Abstract: In order to investigate the effect of high-cholesterol seafood intake on serum lipid in healthy human, thirty-three healthy volunteers aged from 22 to 28 years including 16 males and 17 females were given 100 g of dietary squid daily for 20 consecutive days. Blood samples were collected on days 0, 10 and 20 of the trail to assay serum lipid, blood glucose, liver function index and fatty acid composition. The results showed that the intake of dietary squid could result in a significant decrease in serum TG level after 9 days. Serum total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C) and glucose level were not changed due to the intake of dietary squid. Meanwhile, dietary squid markedly changed serum fatty acid composition, and significantly increased EPA and DHA levels. These findings revealed that the intake of dietary squid at the dose of 100 g/d has no effect on serum cholesterol concentration in normal human, suggesting that squid consumption should not be a cause of arteriosclerosis.

Key words: squid, cholesterol, triglyceride, serum lipid, nutrition intervention, arteriosclerosis