FOOD SCIENCE ›› 2011, Vol. 32 ›› Issue (7 ): 296-299.doi: 10.7506/spkx1002-6630-201107065

• Nutrition & Hygiene • Previous Articles     Next Articles

Anti-hypertensive Effect of Extract from Purple Laver (Porphyra yezoensis) in Rat

REN Shan-shan1,LI Peng-gao1,*, TANG Yu-ping2,ZHANG Shu-hua1,XIAO Zhong-xin1,WU Hui-hui1,WEI Shou-gang1   

  1. 1. School of Public Health and Family Medicine, Capital Medical University, Beijing 100069, China;
    2. Yanjing Medical College, Capital Medical University, Beijing 101300, China
  • Received:2010-08-30 Revised:2011-02-23 Online:2011-04-15 Published:2011-03-30

Abstract: In order to investigate the anti-hypertensive effects of various extracts from purple laver (Porphyra yezoensis), spontaneously hypertensive rats (SHR) administered with extracts from purple laver by intragastric infusion and the change in blood pressure (BP) of the rats was monitored by carotid artery catherization. The results showed that water and ethanol extracts from purple laver had no effect on BP in SHR, but neutral protease and pepsin hydrlysates of purple laver had a significant BP-lowering effect. No adverse effect on heart rate and BP in normotensive Wistar-Kyoto rats was observed. The decreasing sequence of BP-lowering effect of the neutral protease and pepsin hydrlysates and captopril was found as follows: captopril > neutral protease hydrolysate > pepsin hydrolysate. Based on this study, it could be concluded that peptides derived from neutral protease or pepsin hydrolysis of purple laver protein have an anti-hypertensive effect in SHR.

Key words: Porphyra yezoensis, extract, common carotid artery, hypertension

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