Abstract: The extraction technology of flavonoids from Robinia persudoscacia seeds was studied using quadratic general spinning design. The results showed that the extraction rate of flavonoids is mostly influenced by ethanol concentration,followed by microwave power,time and material to liquid ratio. The ethanol concentration and microwave power and the interaction between them have most significant effects on the extraction rate of flavonoids,and the effect of the microwave time takes second place,but the material to liquid ratio has no significant effect. The optimum process parameters are ethanol concentration 60%,microwave power 800 W,extraction time 40 s and material to liquid ratio 1:30. Under these conditions,the theory extraction rate of flavonoids from Robinia persudoscacia seeds is 31.99 mg/g. The result of verification experiment is 31.47 mg/g,close to that.

Key words: Robinia persudoscacia seeds, flavonoids, microwave-assisted extraction, quadratic general spinning design