FOOD SCIENCE ›› 2005, Vol. 26 ›› Issue (6): 225-228.

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Mechanisms of the Proliferation of Human Breast Cancer Cell MCF-7 by Isoflavone Genistein

 ZHANG  Guo-Fu, LI  Zhong, MO  Bao-Qing   

  1. Department of Nutrition and Food Science in School of Public Heath of Nanjing Medical University
  • Online:2005-06-15 Published:2011-09-19

Abstract: The effects of genistein on the proliferation of human breast cancer cell MCF-7 was studied. Genistein inhibited the proliferation of MCF-7 cells significantly, arrested cell cycle progression at G 2 /M phase, and enhanced cyclin B protein expression in dose-dependent manner. No effect on cyclin E protein expression was observed. Genistein reduced bcl-2 protein expression , induced bax protein expression and reduced the ratio of bcl-2/bax .

Key words: genistein, MCF-7, bcl-2,cell cycle