Abstract:

In order to study the effects of long-term dietary intake of genistein which starts from maternal mice on the blood
lipids and liver of female and male offspring, maternal mice were orally adminstered with 0, 5, 25 and 50 mg/(kg·d) of
genistein, and the administrations were conducted on the offspring instead of the mother mice after birth. On the 21st, 42nd
and 80th days after birth, the contents of serum triglycerides (TG), total cholesterol (TC), low-density lipoprotein cholesterol
(LDL-C) of the female and male offspring were detected, and liver morphology were observed by hematoxylin-eosin (HE)
stained section. The results showed that long-term dietary genistein intake significantly reduced the serum levels of TC, TG
and LDL-C of the offspring mice and serum LDL-C was decreased more significantly in the male offspring. HE staining
showed that liver steatosis could be more serious and potentially be developed into cirrhosis in response to genistein intake.

Key words: genistein, ICR mice, serum lipid, liver, hematoxylin-eosin (HE) staining