Abstract:

Objective: To investigate the mechanism of action of resistant starch (RS) and Ganoderma lucidum spore powder
(GLSP) on glycolipid metabolism and oxidative stress in type 2 diabetic rats. Methods: Diabetic rats were induced by
streptozocin (STZ). The effects of RS and GLSP on blood glucose, blood lipid and oxidative stress index were investigated.
Results: RS and GLSP could improve the content of blood glucose and exert antioxidant effect. While RS had stronger
antioxidant capability than GLSP, GLSP had an advantage in improving lipid metabolism disorder over RS and there
was a synergistic effect between them. The antioxidant capacity was further enhanced through the intervention with RS.
Conclusion: The mode of synergistic intervention and simultaneous consumption of RS and GLSP can effectively reduce
blood glucose, improve lipid metabolism, and enhance antioxidant capability. This mode is a better dietary intervention
method of preventing diabetes and improving diabetic symptoms.

Key words: resistant starch, Ganoderma lucidum spore, diabetes, blood glucose, blood lipid, oxidative stress