Abstract: For ammonium perfluorooctanoate (APFO),a representative substance of perfluorooctane salts,the acute oral toxicity of rat LD50 is 584 mg/kg with 95% reliability (430～94 mg/kg). It is a slight skin irritant substance,with reproductive toxicity,germ cell mutagenicity,specific target organ systemic toxicity of single exposure and repeated exposure. The detection results of APFO in liver and serum also prove its specific target organ systemic toxicity and reproductive toxicity.

Key words: food, packaging materials, APFO, toxicology