Study on Preparation of Lycopene Nanoliposomes

Abstract

Abstract: Objective:To prepare lycopene nanoliposomes. Methods:Lycopene nanoliposomes were prepared by conventional rotary evaporated film-ultrasonication. Taking the entrapment efficiency of lycopene nanoliposomes as the main evaluation index,the prescription of the lycopene nanoliposomes was optimized by orthogonal design. Results:The best ratio of lycopene to cholesterol to phospholipids is 2:15:100. The optimum pH value of the water phase phosphate buffer solution is 7.0 and the temperature is 34 ℃. With the optimized operation,the average entrapment efficiency of nanoliposomes is 49.88 %± 0.19%,the drug is 0.86% ± 0.1%,and the particle size is below 40 nm. Conclusion:The optimized operation is reasonable and practicable to pepare lycopene nanoliposomes with low particle size and homogeneous microspheres shape.

Key words: lycopene, nanoliposomes

FAN Yuan-Jing, ZHANG Bi-Fang, LIU Yan. Study on Preparation of Lycopene Nanoliposomes[J]. FOOD SCIENCE, 2008, 29(12): 238-241.

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Study on Preparation of Lycopene Nanoliposomes

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