Study on Effects of Dietary BRF on Cholesterol Metabolism of apoE-deficient Mice to Inhibit Athelogenesis

Abstract

Abstract: To explore the effect of dietary black rice pericarp fraction(BRF)on cholesterol metabolism,and to elucidate the mechanismof BRF anti -atherogenesis in apoE -deficient mi ce.After16weeks feed by 5%BRF,cholesterol levels in serum,liver and aorta of different groups were determined by enzymatic method.The stu dy suggestedthatmiceinBRFfed grouphadlowertotalcholesterollevels in serum,liverandaorta incomparison with control WRF white rice pericarp fraction.At the same time,BRF group had h igher HDL -C level compared to controlgroup.Dietary BRFcouldinp rove cholesterolmetabolisminapoE-deficientmice andthis effectmigh tbe one of the possible mechanisms by whi ch BRFcould inhibit atherogenesis.

Key words: apoE-deficient mice, black rice pericarp fraction, white rice pericarp fraction, cholesterol

XIA Min, MA Jing, TANG Zhi-Hong, ZHANG Yu-Mei, LING Wen-Hua. Study on Effects of Dietary BRF on Cholesterol Metabolism of apoE-deficient Mice to Inhibit Athelogenesis[J]. FOOD SCIENCE, 2003, 24(1): 114-118.

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Study on Effects of Dietary BRF on Cholesterol Metabolism of apoE-deficient Mice to Inhibit Athelogenesis

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