Regulation of Cholesterol Metabolism by Sulfated Polysaccharides from Morchella angusticeps Peck

doi:10.7506/spkx1002-6630-20190318-217

Abstract

Abstract: Polysaccharide extracted from Morchella angusticeps Peck (PMEP) has been proved to have a hypocholesterolemic effect. This study aimed to compare the cholesterol-lowering activity of PMEP and its sulfated derivative (SPMEP) in rats fed on a high-cholesterol diet. Results showed that PMEP at high dose and SPMEP could decrease serum total cholesterol by 15% and 23%, respectively, indicating that SPMEP had a stronger cholesterol-lowering potency than PMEP (P < 0.05). PMEP and SPMEP down-regulated the expression of hepatic 3-hydroxy-3-methyl-glutaryl-coenzyme A reductase and up-regulated the expression of cholesterol-7α-hydroxylase (P < 0.05). Besides, both of them could decrease liver cholesterol, while significantly increasing the excretion of total fecal and intestinal bile acids (P < 0.05). Therefore, the cholesterol-lowering activity of PMEP in rats can be enhanced after being sulfated.

Key words: Morchella angusticepes Peck, polysaccharide, sulfation, cholesterol metabolism

CLC Number:

TS201.4

TANG Yuwan, ZHANG Yueqiao, LI Yao, LEI Lin, LI Fuhua, ZHAO Jichun, WU Surui, MING Jian. Regulation of Cholesterol Metabolism by Sulfated Polysaccharides from Morchella angusticeps Peck[J]. FOOD SCIENCE, 2019, 40(21): 136-142.

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Regulation of Cholesterol Metabolism by Sulfated Polysaccharides from Morchella angusticeps Peck

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