Effect of Lb.casei Zhang on Koumiss on the Production of Cytokines in Sera of Mouse

Abstract

Abstract: Objective: To explore and evaluate the effects of Lb.casei Zhang on the production level of IFN-γ,IL-12,IL-1α,TNF-αin sera of mice. MethodBy ELISA assay the contents of IFN-γ,IL-12,IL-1α and TNF-αwere examined in sera of mice after 18d arally administrated with three variety of dosege of heat-killing and living Lb.casei Zhang,which were isolated from koumiss and could resist acid artifical gastric and intestinal juice. ResultIt showed that living Lb.casei Zhang with the high and middle content significanyly increased the content of IFN-γand IL-12 in sera of mice (p<0.05),and IL-1αandTNF-αwere decreased greatly (p<0.01). Heat-killing Lb.casei Zhang had no appreciable effect on cytokine. Conclusion: The immuno- modulation effect of living L.casei Zhang is better than that heat-killing L.casei Zhang,it is favorable for immuno-modulation on many aspect.

Key words: , Lb.casei Zhang； cytokine；

TUO Ya, SU Ya-Le-Ma, Zhang-He-Ping. Effect of Lb.casei Zhang on Koumiss on the Production of Cytokines in Sera of Mouse[J]. FOOD SCIENCE, 2006, 27(11): 488-491.

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Effect of Lb.casei Zhang on Koumiss on the Production of Cytokines in Sera of Mouse

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