Abstract: The conditions of extracting proanthocyanidins from grape seeds were studied in this paper. The following conditionswere established: 70% acetone or 70% ethanol, the ratio of the solid material to solution 1:4 and the extracting time 8～10hat room temperature. The proanthocyanidins by acetone fractionated after the extraction of ethyl acetate. The yield of ethylacetate extraction was 14.4%～31.6%, with a purity over 32% while the yield of acetone ffrachionation was 54.3%～63.5%with a purity over 27.9% with a purity.

Key words: Proanthocyanidins , Grape seed , Ectraction and fractionation