Anti-fatigue Effects of Polysaccharides Derived from Dendrobium nobile Lindl. in Mice

Abstract

Abstract: Purpose: To investigate the anti-fatigue effects of polysaccharides derived from Dendrobium nobile Lindl (DNP) in mice. Methods: The anti-fatigue effect of polysaccharides was evaluated based on the forced swimming performance and the changes of biochemical parameters in ICR mice. Mice were orally administrated with DNP at a dose of 500 mg/(kg·d) day for 4 successive weeks to create a treatment group and those given distilled water every day were assigned to a control group. After the end of the 4-week administration period, all mice were subjected to weight-loaded forced swim test and then measured for swimming time and biochemical indicators such as blood triglyceride, blood sugar, blood ammonia and glycogen. Results: Compared with distilled water, DNP especially alkaline-soluble DNP could significantly lengthen the swimming time of mice, increase blood triglyceride and glucose levels, and reduce blood lactic acid and ammonia levels, and post-swimming hepatic and muscle glycogen consumption in mice. Conclusion: DNP can exert anti-fatigue effects in mice by increasing fat utilization and delaying the accumulation of plasma lactic acid and ammonia.

Key words: anti-fatigue effect, Dendrobium nobile, glycogen, lactic acid

CLC Number:

Q946.3

References

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