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Effect of Bacillus subtilis JS01 on Lipid Metabolism in Hyperlipidemic Mice

ZENG Dong1,2,LIU Yu-zhi1,TANG Chao1,QUAN Hong-yang1,ZHANG Hai-ming1,NI Xue-qin1,2,*   

  1. 1. Research Institute of Microecology, College of Veterinary Medicine, Sichuan Agricultural University, Ya’an 625014, China;
    2. Key Laboratory for Animal Disease and Human Health of Sichuan Province, Ya’an 625014, China
  • Online:2013-07-15 Published:2013-06-28
  • Contact: NI Xue-qin

Abstract:

Objective: To explore the effect of Bacillus subtilis JS01 on lipid metabolism in hyperlipidemic mice. Methods:
Ninety Kunmng mice were randomly divided into normal control group (Group Ⅰ), high-fat model group (Group Ⅱ) and highfat
+ Bacillus subtilis group (Group Ⅲ). Ten mice were selected from each group and killed on the 15th (D15), 30th (D30) and
45th (D45) days of the experiment, respectively. Triglycerides (TG), total cholesterol (TC), low-density lipoprotein cholesterol
(LDL-C) and high-density lipoprotein cholesterol (HDL-C) in serum and hormone-sensitive lipase (HSL) activity level in liver
were detected. Results: 1) At the three time points, serum TC, LDL-C, HDL-C and LDL-C/HDL-C ratio in Group Ⅱ were
higher than that in Group Ⅰ (P < 0.05, P < 0.01). 2) At D15 and D30, serum TG in Group Ⅱ was higher than that in Group
Ⅰ and Group Ⅲ. At D30 and D45, serum HDL-C in Group Ⅲ was higher than that in Group Ⅱ (P < 0.05). 3) At D45, liver
HSL activity in Group Ⅲ was higher than that in Group Ⅰ and Group Ⅱ (P < 0.01). Conclusion: Bacillus subtilis JS01 has
hypolipidemic effect to some extent by improving HDL-C in serum and HSL activity in liver, while reducing TG, TC and
LDL-C in serum of hyperlipidemic mice.

Key words: Bacillus subtilis, hyperlipidemia, lipid metabolism, hormone-sensitive lipase

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