Abstract: Sugarcane vinegar contains abundant polyphenols and flavonoids and has good antioxidant activity. Given this background, this study explored the effect of sugarcane vinegar on blood lipids, liver lipids and redox capacity including the activity of glutathione peroxidase (GSH-Px), nitric oxide synthase (NOS) and superoxide dismutase (SOD) and the content of malondialdehyde (MDA) in a mouse model of lipid metabolism disorder induced by a high-fat diet. The results showed that compared with the high fat control group, oral administration with sugarcane vinegar could significantly decrease plasma total cholesterol (TC) (P < 0.05), lower triglyceride (TG) and low-density lipoprotein cholesterol (P < 0.01) and increase high-density lipoprotein cholesterol (P < 0.01). At the same time, blood ?amylase activity was significantly decreased (P < 0.01) and lipase activity was significantly increased (P < 0.01), so that blood glucose level and fat accumulation could be reduced. The activity of SOD and GSH-Px in plasma and liver were improved, and NOS activity and MDA content of the lipid peroxidation products in liver were decreased. Therefore, sugarcane vinegar can function to regulate blood lipids, reduce body mass and hepatomegaly and improve oxidative stress resistance, thereby helping slow down the occurrence and development of hyperlipidemia, and obesity and its complications.

Key words: sugarcane vinegar, lipid metabolism, oxidative stress, mice fed high-fat diet