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Progress in Studies on Oxidation Products of Linoleic Acid Leukotoxin and Leukotoxin Diols

SONG Hui1,2, GENG Zhiming1,*, REN Shuang1,2, WANG Daoying1, DU Panpan1,2, ZHANG Muhan1, SUN Chong1, LIU Fang1, XU Weimin1   

  1. 1. Institute of Agricultural Products Processing, Jiangsu Academy of Agricultural Sciences, Nanjing 210014, China;
    2. Key Laboratory of Meat Processing and Quality Control, Ministry of Education, Nanjing Agricultural University, Nanjing 210095, China
  • Online:2016-03-15 Published:2016-03-17

Abstract:

Leukotoxin (Ltx) and leukotoxin diol (Ltxd) are oxidation products of linoleic acid (LA). The existing studies
indicate that both Ltx and Ltxd are cytotoxic and associated with a number of mammalian diseases. Exogenous Ltx and Ltxd
can disrupt the endocrine function in female rats. The present paper reviews the recent progress made in the studies of Ltx
and Ltxd with respect to discovery, mechanisms of formation, pathological and physiological significance, toxicological
effects and analytical methods. Moreover, further studies in this area are also suggested.

Key words: linoleic acid, lipid oxidation, leukotoxin, leukotoxin diol

CLC Number: