Abstract:

Purpose: To explore the effect of blueberry leaf polyphenols (BLP) at different doses on blood lipids and
liver parameters in mice. Methods: Totally 60 healthy mice were randomly divided into 6 groups, including basic group,
hyperlipidemic model group, BLP low, middle and high dose groups (at 50, 150 and 300 mg/(kg·d), respectively), and positive
control group (lipitor at 3 mg/(kg·d)). The administration lasted for 30 days, and then blood samples were harvested from the
eyeballs, and the mice were sacrificed for the collection of liver tissues. The serum lipids and liver indexes were determined.
Results: The mice administered with BLP at 50 mg/(kg·d) revealed significant decreases in serum TC and LDL-C levels
compared with the model mice (P < 0.05); meanwhile, the activity of glutamic oxalacetic transaminase (AST) in liver was
lower by 26.7% than that ((329.57 ± 15.06) U/g pro) of the model mice. When the dose was increased to 150 mg/(kg·d), the
levels of TC, TG and LDL-C in serum as well as AST activity in liver were significantly decreased when compared with those
in the model group (P < 0.05); in contrast, HDL-C was significantly higher than that in the model group (P < 0.05). When
the dose was further increased to 300 mg/(kg·d), serum TC, TG and LDL-C were reduced significantly (P < 0.05), but serum
HDL-C was increased in comparison with the model group (P < 0.05); the liver index was (4.19 ± 0.14)%, lower than that
((4.98 ± 0.33)%) of the model group, and the activities of AST and alanine transaminase (ALT) in live declined
by 32.15% and 22.96% when compared with those in the model group, which were (329.57 ± 15.06) U/g pro and
(354.31 ± 23.31) U/g pro), respectively. Conclusion: Blueberry leaf polyphenols have the potential for regulating blood
lipids and protecting the liver.

Key words: blueberry leaf polyphenols, blood lipid, liver