Bifidobacterium BB12 Promotes Defecation and Regulates Gastrointestinal Hormones in Constipated Rats

doi:10.7506/spkx1002-6630-201613037

Abstract

Abstract:

Objective: To investigate the effects of Bifidobacterium BB12 on promoting defecation and regulating
gastrointestinal hormones in constipated rats. Methods: Totally 48 Wistar rats, half male and half female, were divided
randomly into control group, positive control group, model group, Bifidobacterium BB12 low-, middle-, and high-dose
groups. Rat models of loperamide hydrochloride-induced constipation were established and the rats from each group were
treated with corresponding drugs. During the experiment, daily food intake, water intake, body weight, fecal number, fecal
water content, gastrointestinal transit, and the contents of gastrin, motilin, substance P and somatostatin in serum were
measured. Results: Fecal number, gastrointestinal transit, and the serum contents of motilin and substance P increased
significantly, while water intake and somatostatin content decreased significantly in response to the administration of
Bifidobacterium BB12. These effects were dependent on gender and dose. There was no significant difference in food intake,
body weight, fecal water content and serum gastrin. Conclusion: The laxative effect of Bifidobacterium BB12 is confirmed
and the underlying mechanism is related to regulating some gastrointestinal hormones.

Key words: Bifidobacterium, constipation, gastrointestinal hormone

CLC Number:

R33
TS201.3

TIAN Ying, DAI Qianqian, SHI Minghui, MENG Chanfang, HUANG Yujun, GU Ruixia. Bifidobacterium BB12 Promotes Defecation and Regulates Gastrointestinal Hormones in Constipated Rats[J]. FOOD SCIENCE, doi: 10.7506/spkx1002-6630-201613037.

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