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Effect of Dietary Blend of Corn Oil and Lard at a Ratio of 1:1 on Blood Lipid, Liver Function and Liver Antioxidant Capacity in Mice

WANG Ji1,2, YAN Sisi1,2, XIE Wen1,2, ZHOU Huijuan1,2, HUANG Haibin1,2, LIU Biying1,2, FENG Chunhong1, WEN Lixin1,2,*   

  1. 1. College of Veterinary Medicine, Hunan Agricultural University, Changsha 410128, China; 2. Hunan Synthetic Innovation Center for Livestock Production Safety, Changsha 410128, China
  • Online:2017-03-15 Published:2017-03-28

Abstract: Objective: To explore the effect of dietary blend of corn oil and lard at a ratio of 1:1 on blood lipid, liver function and liver antioxidant capacity in mice by simulating Chinese dietary habits. Methods: A total of 24 eight-week male SPF Kunming mice were randomly divided into blank, recommended intake and actual intake groups, which were fed a basal diet supplemented with 0%, 3.8%, and 6.5% of the oil blend, respectively. After 8 weeks, body weight was measured, and peripheral blood was collected for determining serum lipids and liver function indices. The intact liver tissue was collected for the calculation of liver index and morphological and histological examination under microscope. Moreover, liver homogenate was prepared for evaluation of oxidative stress. Results: The liver index in mice was positively correlated with the dietary amount of the oil bend. Alanine transaminase (ALT), aspartate transaminase (AST) and alkaline phosphatase (ALP) activities in mice from the blank group were significantly higher than those in mice from the recommended intake and actual intake groups. However, total antioxidant capacity in the liver of mice from the recommended intake group was significantly higher than in mice from the blank and actual intake groups. Oxidative liver injury in mice from the blank group was significantly greater than in mice from the two other groups. Conclusion: Insufficient dietary oil has a negative effect on liver function in mice. The recommended intake of corn oil/lard blend at 1:1 can enhance liver antioxidant capacity in mice and reduce oxidative damage.

Key words: corn oil, lard, oil blend, blood lipid, liver function, antioxidant

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