Abstract: Emerging evidence suggests that metabolic syndrome, cardiovascular diseases and colorectal cancer are closely associated with the gut microbiota, and the role of these bacteria in the treatment of these diseases has gained considerable research attention, but the pathogenesis and the causal relationship between the gut microbiota and these diseases have not been elucidated to date. The objective of this review is to analyze the changes in structure and species composition as well as metabolic activities of the gut microbiota that can affect the regulation of blood pressure. The association between the gut microbiota and hypertension is discussed in this article. Probiotics are live organisms that are benefit for health and helpful to regulate the balance of the gut ecology. This regulation plays a key role in blood pressure control. In addition, the effect of probiotics on the activity of the gut microbiota is also investigated. Finally, the potential application of gut microbiome as a target in the development of novel therapy for hypertension will be an important research area.

Key words: probiotic, gut microbiome, hypertension