Ambient Mass Spectrometry and Imaging in Food Safety Screening

Abstract

Abstract: With the growing demand for food safety detection, traditional analytical methods face significant technical challenges, such as lengthy detection cycles and low efficiency, particularly when dealing with complex food matrices and large sample volumes. Ambient ionization mass spectrometry (AIMS) has emerged as a cutting-edge rapid analytical tool, demonstrating remarkable advantages in food safety detection due to its minimal or simplified sample preparation requirements. Characterized by high analytical speed and efficiency, AIMS has been successfully applied to the rapid detection of various hazardous substances in food, including pesticide and veterinary drug residues, chemical contaminants, and toxins. Furthermore, ambient ionization mass spectrometry imaging (AIMSI) provides spatial distribution information of chemical compounds on sample surfaces, offering a visual basis for in situ sampling. This review systematically outlines the development and classification of AIMS, with a focus on its current applications in the field of food safety. Additionally, it delves into the latest research advancements in AIMSI. The aim of this review is to provide theoretical foundations and technical guidance for the selection and application of AIMS and its imaging technologies in rapid food safety detection.

Key words: Food Safety, Ambient Mass Spectrometry, Mass Spectrometry Imaging, Rapid Detection

CLC Number:

育航袁洁廉洁廉绘超王 yuan yuhang. Ambient Mass Spectrometry and Imaging in Food Safety Screening[J]. FOOD SCIENCE.

References

[1]郑行军.食品质量安全管理问题及解决措施探讨[J].现代食品, 2024, 30(13):149-151 [2]邵瑞婷, 丁学妍, 姜洁.超高效液相色谱-串联质谱法测定调节三高类保健食品中种非法添加药物[J].食品科学, 2024, 45(9):232-242 [3]于家斌, 范依云, 王小艺, 等.基于优化的灰色关联分析-极限学习机食用油污染物风险评价模型研究[J].食品科学, 2023, 44(3):88-97 [4]史娜, 侯彩云, 路勇, 等.高效液相色谱-质谱法检测食品中种真菌毒素[J].食品科学, 2014, 35(16):190-196 [5]杨志金, 林彬彬, 黄旭良, 等.基于大气压化学电离的-法测定动物源性食品中种酰胺类除草剂残留[J].食品科学, 2023, 44(22):373-379 [6]张蕴哲, 张先舟, 袁耀武, 等.免疫亲和层析技术协同酶联免疫吸附法检测赭曲霉毒素[J].食品科学, 2024, 45(10):10257-10264 [7]何荣强.基于纸基检测技术的应用及研究进展[J].质量安全与检验检测, 2024, 34(2):64-67 [8]LASKIN J, LANEKOFF I.Ambient Mass Spectrometry Imaging Using Direct Liquid Extraction Techniques[J].Analytical Chemistry, 2016, 88(1):52-73 [9]GAZELI O, A.ELIA E,ARGIRUSIS N,et alLow-cost heat assisted ambient ionization source for mass spectrometry in food and pharmaceutical screening[J].Analyst, 2024, 149(17):4487-4495 [10]GROSS J H.Direct analysis in real time—a critical review on DART-MS[J].Analytical and Bioanalytical Chemistry, 2014, 406(1):63-80 [11]TAKáTS Z, WISEMAN J M, GOLOGAN B, et al.Mass Spectrometry Sampling Under Ambient Conditions with Desorption Electrospray Ionization[J].Science, 2004, 306(5695):471-473 [12]YANG S, DING J, ZHENG J, et al.Detection of Melamine in Milk Products by Surface Desorption Atmospheric Pressure Chemical Ionization Mass Spectrometry[J].Analytical Chemistry, 2009, 81(7):2426-2436 [13]CODY R B, LARAMéE J A, DURST H D.Versatile New Ion Source for the Analysis of Materials in Open Air under Ambient Conditions[J].Analytical Chemistry, 2005, 77(8):2297-2302 [14]CHENG S C, SHIEA C, HUANG Y L, et al.Laser-based ambient mass spectrometry[J].Analytical Methods, 2017, 9(34):4924-4935 [15]GEBALLA-KOUKOULA A, GERSSEN A, NIELEN M W F.From Smartphone Lateral Flow Immunoassay Screening to Direct MS Analysis: Development and Validation of a Semi-Quantitative Direct Analysis in Real-Time Mass Spectrometric (DART-MS) Approach to the Analysis of Deoxynivalenol[J].Sensors, 2021, 21(5):1861-1861 [16]PITMAN C N, LACOURSE W R.Desorption atmospheric pressure chemical ionization: A review[J].Analytica Chimica Acta, 2020, 1130(1):146-154 [17]WEIDNER L, HEMMLER D, RYCHLIK M, et al.Real-Time Monitoring of Miniaturized Thermal Food Processing by Advanced Mass Spectrometric Techniques[J].Analytical Chemistry, 2023, 95(2):1694-1702 [18]GAMBOA-BECERRA R, MONTERO-VARGAS J M, MARTíNEZ-JARQUíN S, et al.Rapid Classification of Coffee Products by Data Mining Models from Direct Electrospray and Plasma-Based Mass Spectrometry Analyses[J].Food Analytical Methods, 2017, 10(5):1359-1368 [19]GUO T, FANG P, JIANG J, et al.Rapid screening and quantification of residual pesticides and illegal adulterants in red wine by direct analysis in real time mass spectrometry[J].Journal of Chromatography A, 2016, 1471(1):27-33 [20]BENTAYEB K, ACKERMAN L K, BEGLEY T H.Ambient Ionization–Accurate Mass Spectrometry (AMI-AMS) for the Identification of Nonvisible Set-off in Food-Contact Materials[J].Journal of Agricultural and Food Chemistry, 2012, 60(8):1914-1920 [21]SILVA L C da, PEREIRA I, CARVALHO T C de, et al.Paper spray ionization and portable mass spectrometers: a review[J].Analytical Methods, 2019, 11(8):999-1013 [22]PAINE M R L, BARKER P J, BLANKSBY S J.Ambient ionisation mass spectrometry for the characterisation of polymers and polymer additives: A review[J].Analytica Chimica Acta, 2014, 808(1):70-82 [23]IBá?EZ C, SIMó C, GARCíA-CA?AS V, et al.The role of direct high-resolution mass spectrometry in foodomics[J].Analytical and Bioanalytical Chemistry, 2015, 407(21):6275-6287 [24]RAWEL H M, ROHN S, KROLL J, et al.Surface enhanced laser desorptions ionization-time of flight-mass spectrometry analysis in complex food and biological systems[J].Molecular Nutrition & Food Research, 2005, 49(12):1104-1111 [25]MASUCCI C, NAGORNOV K O, KOZHINOV A N, et al.Evaluation of atmospheric-plasma-source absorption mode Fourier transform Orbitrap mass spectrometry for chlorinated paraffin mixtures[J].Analytical and Bioanalytical Chemistry, 2024, 416(23):5133-5144 [26]SENYUVA H Z, G?KMEN V, SARIKAYA E A.Future perspectives in OrbitrapTM-high-resolution mass spectrometry in food analysis: a review[J].Food Additives & Contaminants: Part A, 2015, 32(10):1568-1606 [27]GARCíA-PARRA M, ROA-ACOSTA D, GARCíA-LONDO?O V, et al.Structural Characterization and Antioxidant Capacity of Quinoa Cultivars Using Techniques of FT-MIR and UHPLCESI-Orbitrap MS Spectroscopy[J].Plants, 2021, 10(10):2159-2159 [28]CARERI M, BIANCHI F, CORRADINI C.Recent advances in the application of mass spectrometry in food-related analysis[J].Journal of Chromatography A, 2002, 970(1):3-64 [29]YANG N, SIMON J, FANG W, et al.Development of analytical “aroma wheels” for Oolong tea infusions (Shuixian and Rougui) and prediction of dynamic aroma release and colour changes during “Chinese tea ceremony” with machine learning[J].Food Chemistry, 2025, 464(1):141537-141537 [30]SNYDER D T, PULLIAM C J, OUYANG Z, et al.Miniature and Fieldable Mass Spectrometers: Recent Advances[J].Analytical Chemistry, 2016, 88(1):2-29 [31]CHEN C H, LIN Z, TIAN R, et al.Real-Time Sample Analysis Using a Sampling Probe and Miniature Mass Spectrometer[J].Analytical Chemistry, 2015, 87(17):8867-8873 [32]CHEN C H, LIN Z, TIAN R, et al.Real-Time Sample Analysis Using a Sampling Probe and Miniature Mass Spectrometer[J].Analytical Chemistry, 2015, 87(17):8867-8873 [33]HUANG M Z, CHENG S C, CHO Y T, et al.Ambient ionization mass spectrometry: A tutorial[J].Analytica Chimica Acta, 2011, 702(1):1-15 [34]PORTA M.Human contamination by environmental chemical pollutants: Can we assess it more properly?[J].Preventive Medicine, 2012, 55(6):560-562 [35]GAZELI O, ELIA E A, ARGIRUSIS N, et al.Low-cost heat assisted ambient ionization source for mass spectrometry in food and pharmaceutical screening[J]. Analyst, 2024, 149(1), 4487-4495.[J].Analyst, 2024, 149(1):4487-4495 [36]GERBIG S, STERN G, BRUNN H E, et al.Method development towards qualitative and semi-quantitative analysis of multiple pesticides from food surfaces and extracts by desorption electrospray ionization mass spectrometry as a preselective tool for food control[J].Analytical and Bioanalytical Chemistry, 2017, 409(8):2107-2117 [37]SHIEA C, HUANG Y L, LIU D L, et al.Rapid screening of residual pesticides on fruits and vegetables using thermal desorption electrospray ionization mass spectrometry[J].Rapid Communications in Mass Spectrometry, 2015, 29(2):163-170 [38]CHEN S, CHANG Q, YIN K, et al.Rapid Analysis of Bisphenol A and Its Analogues in Food Packaging Products by Paper Spray Ionization Mass Spectrometry[J].Journal of Agricultural and Food Chemistry, 2017, 65(23):4859-4865 [39]PEREIRA I, RODRIGUES S R M, CARVALHO T C de, et al.Rapid screening of agrochemicals by paper spray ionization and leaf spray mass spectrometry: which technique is more appropriate?[J].Analytical Methods, 2016, 8(31):6023-6029 [40]MULLIGAN C C, TALATY N, COOKS R G.Desorption electrospray ionization with a portable mass spectrometer: in situ analysis of ambient surfaces[J].Chemical Communications, 2006, 1(16):1709-1711 [41]JENG J, JIANG Z, CHO Y, et al.Obtaining molecular imagings of pesticide residues on strawberry surfaces with probe sampling followed by ambient ionization mass spectrometric analysis[J].Journal of Mass Spectrometry, 2021, 56(4):4644-4644 [42]CHEN K H, LI Y C, SHEU F, et al.Rapid screening and determination of pesticides on lemon surfaces using the paper-spray mass spectrometry integrated via thermal desorption probe[J].Food Chemistry, 2021, 363(1):130-305 [43]WANG H, LIU J, COOKS R G, et al.Paper Spray for Direct Analysis of Complex Mixtures Using Mass Spectrometry[J].Angewandte Chemie International Edition, 2010, 49(5):877-880 [44]SHEN L, ZHANG J, YANG Q, et al.High throughput paper spray mass spectrometry analysis[J].Clinica Chimica Acta, 2013, 420(1):28-33 [45]CHENG S C, LEE R H, JENG J Y, et al.Fast screening of trace multiresidue pesticides on fruit and vegetable surfaces using ambient ionization tandem mass spectrometry[J].Analytica Chimica Acta, 2020, 1102(1):63-71 [46]LUOSUJ?RVI L, KANERVA S, SAARELA V, et al.Environmental and food analysis by desorption atmospheric pressure photoionization-mass spectrometry[J].Rapid Communications in Mass Spectrometry, 2010, 24(9):1343-1350 [47]LI X Q, LI H M, XU S, et al.Rapid quantification of trace chloramphenicol in honey under ambient conditions using direct analysis via real-time QTRAP mass spectrometry[J].Food Chemistry, 2019, 276(1):50-56 [48]PASEIRO-CERRATO R, ACKERMAN L, DE JAGER L, et al.Brominated flame retardants (BFRs) in contaminated food contact articles: identification using DART-HRMS and GC-MS[J].Food Additives & Contaminants: Part A, 2021, 38(2):350-359 [49]OSORIO J, AZNAR M, NERíN C, et al.Comparison of LC-ESI,DART,and ASAP for the analysis of oligomers migration from biopolymer food packaging materials in food (simulants)[J].Analytical and Bioanalytical Chemistry, 2022, 414(3):1335-1345 [50]SOARES D de A, PEREIRA I, SOUSA J C P, et al.Bisphenol determination in UHT milk and packaging by paper spray ionization mass spectrometry[J].Food Chemistry, 2023, 400(1):134014-134014 [51]DA SILVA LIMA G, FRANCO DOS SANTOS G, RAMALHO R R F, et al.Laser ablation electrospray ionization mass spectrometry imaging as a new tool for accessing patulin diffusion in mold-infected fruits[J].Food Chemistry, 2022, 373(1):131490-131490 [52]GEBALLA-KOUKOULA A, GERSSEN A, BLOKLAND M H, et al.Immuno-Enriched Microspheres - Magnetic Blade Spray-Tandem Mass Spectrometry for Domoic Acid in Mussels[J].Analytical Chemistry, 2021, 93(47):15736-15743 [53]BLACK C, CHEVALLIER O P, ELLIOTT C T.The current and potential applications of Ambient Mass Spectrometry in detecting food fraud[J].TrAC Trends in Analytical Chemistry, 2016, 82(1):268-278 [54]NIELEN M W F, HOOIJERINK H, ZOMER P, et al.Desorption electrospray ionization mass spectrometry in the analysis of chemical food contaminants in food[J].TrAC Trends in Analytical Chemistry, 2011, 30(2):165-180 [55]SERó R, Nú?EZ O, BOSCH J, et al.Desorption electrospray ionization-high resolution mass spectrometry for the screening of veterinary drugs in cross-contaminated feedstuffs[J].Analytical and Bioanalytical Chemistry, 2015, 407(24):7369-7378 [56]MONTOWSKA M, RAO W, ALEXANDER M R, et al.Tryptic Digestion Coupled with Ambient Desorption Electrospray Ionization and Liquid Extraction Surface Analysis Mass Spectrometry Enabling Identification of Skeletal Muscle Proteins in Mixtures and Distinguishing between Beef,Pork,Horse,Chicken,and Turkey Meat[J].Analytical Chemistry, 2014, 86(9):4479-4487 [57]WU C, DILL A L, EBERLIN L S, et al.Mass spectrometry imaging under ambient conditions[J].Mass Spectrometry Reviews, 2013, 32(3):218-243 [58]张琦玥, 聂洪港.质谱成像技术的研究进展[J].分析仪器, 2018, 1(5):1-10 [59]袁育航, 廉洁, 聂洪港, 等.质谱成像分析毛发中药物的研究进展[J].分析试验室, 2024, 43(10):1497-1504 [60]XUE J, BAI Y, LIU H.Recent advances in ambient mass spectrometry imaging[J].TrAC Trends in Analytical Chemistry, 2019, 120(1):115659-115659 [61]YANG S P, CHEN H W, YANG Y L, et al.Imaging Melamine in Egg Samples by Surface Desorption Atmospheric Pressure Chemical Ionization Mass Spectrometry[J].Chinese Journal of Analytical Chemistry, 2009, 37(3):315-318 [62]GERBIG S, BRUNN H E, SPENGLER B, et al.Spatially resolved investigation of systemic and contact pesticides in plant material by desorption electrospray ionization mass spectrometry imaging (DESI-MSI)[J].Analytical and Bioanalytical Chemistry, 2015, 407(24):7379-7389 [63]KIM J Y, SEO E S, KIM H, et al.Atmospheric pressure mass spectrometric imaging of live hippocampal tissue slices with subcellular spatial resolution[J].Nature Communications, 2017, 8(1):2113-2113 [64]NIELEN M W F, VAN BEEK T A.Macroscopic and microscopic spatially-resolved analysis of food contaminants and constituents using laser-ablation electrospray ionization mass spectrometry imaging[J].Analytical and Bioanalytical Chemistry, 2014, 406(27):6805-6815 [65]ZHANG H, BIBI A, LU H, et al.Comparative study on ambient ionization methods for direct analysis of navel orange tissues by mass spectrometry[J].Journal of Mass Spectrometry, 2017, 52(8):526-533 [66]ZHANG H, CHINGIN K, ZHU L, et al.Molecular Characterization of Ongoing Enzymatic Reactions in Raw Garlic Cloves Using Extractive Electrospray Ionization Mass Spectrometry[J].Analytical Chemistry, 2015, 87(5):2878-2883