Abstract:

Objective: To determine the effect of n-3 PUFA diet on obesity and obesity-related cell factors in mice. Methods: A total of 36 healthy female mice were randomly divided into three groups: high fat diet group, n-3 PUFA-containing diet group and control group. Body weight and food intake were recorded once a weed during the trail period and the levels of serum adiponectin, orexin-A and resistin were determined by ELISA method at the end of the trial. Results: The adiposity and serum orexin-A level in the n-3 PUFA-containing diet group were significantly lower than that in the high fat diet model group (P ＜0.05), and the level of serum resistin in the n-3 PUFA-containing diet model group was significantly higher than that in the high fat diet model group (P ＜ 0.05). Conclusion: An obvious reduction on the development of adiposity was observed in mice fed n-3 PUFA-containing diet.

Key words: n-3 PUFA, obesity, adiponectin, orexin-A, resistin