FOOD SCIENCE ›› 2010, Vol. 31 ›› Issue (13): 297-301.doi: 10.7506/spkx1002-6630-201013068

• Analysis & Detection • Previous Articles     Next Articles

c9t11- and t10c12-CLA: Difference in Biological Functions and Mechanisms

LIU Pei1，SHEN Sheng-rong1，RUAN Hui1，LIU Qi2，HE Guo-qing1,*   

  1. 1. School of Biosystems Engineering and Food Science, Zhejiang University, Hangzhou 310029, China；
    2. Jiaonan Science and Technology Bureau, Qingdao 266400, China
  • Received:2009-12-10 Online:2010-07-01 Published:2010-12-29
  • Contact: HE Guo-qing1,* E-mail:gqhe@zju.edu.cn

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Abstract:

Conjugated linoleic acid (CLA) is a mixture of positional and geometric isomers, and numerous biological functions such as anticancer, reduction of body fat content, diabetes prevention, lower blood lipids and inhibition of arteriosclerosis are due to individual or synergistic action of most isomers including c9t11- and t10c12-CLA. Because of different positions of double bounds between c9t11- and t10c12-CLA isomers, high oxidization possibility of c9t11-CLA isomer was observed. Therefore, c9t11-CLA isomer exhibited a major responsibility for anticarcinogenic effect, whereas, t10c12-CLA isomer exhibited stronger reduction effect on body fat and blood lipids. Increasing studies suggested that the mechanisms of both isomers on cancer and fat metabolism were different.

Key words: c9t11-CLA, t10c12-CLA, anticancer, body composition, fat metabolism

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