Abstract:

Kingming mice were fed high fat diet to establish a hyperlipidemic model. In order to explore the hypolipidemic effect of dietary fibers from Gracilaria sp. (GDF), the mice with hyperlipemia were administered GDF at the dosages of 100, 200 mg/(kg bw·d) and 400 mg/(kg bw·d) for 4 consecutive weeks. Oat dietary fiber was used as the control. Blood lipid indicators including total cholesterol (TC), triglyceride (TG), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C) were determined. GDF could significantly reduce the contents of TC, TG and LDL-C, and increase the content of HDL-C in serum. Therefore, GDF has the potential to regulate lipid metabolism and relieve oxidative injury induced by high fat diet.

Key words: Gracilaria sp., dietary fiber, hyperlipemia