关键词: 双酚A, 液相色谱-串联质谱, 残留

Abstract: A new method was developed for direct determination of biphenol A residue by liquid chromatography tandem mass spectrometer. Sample was concentrated by solid phase extraction column. Selection reaction monitoring technique via negative electrospray ionization was used, and quantitative ion pairs were m/z 227 > m/z 132 and m/z 114. Mobile phase was methanol and water mixture (3:7), with flow rate 500μl/min. The linear range is 18.0～1800.0 ng/ml with a detection limit of 1.8 ng/ml, and the recovery is 91%. Cornparison resuts of UV and LC-MS2 showed that this method is simple, rapid, sensitive and accurate.

Key words: biphenol A, liquid chromatography tandem mass spectrometer, residue