对羟基苯甲酸壳聚糖酯的制备、表征和抗菌活性

食品科学 ›› 2005, Vol. 26 ›› Issue (9): 192-195.

对羟基苯甲酸壳聚糖酯的制备、表征和抗菌活性

赵希荣, 夏文水

江南大学食品学院，淮阴工学院食品工程系

出版日期:2005-09-15 发布日期:2011-09-20

Synthesis, Characterization and Antimicrobial Activity of Para-hydroxybenzoate Chitosan Ester

ZHAO Xi-Rong, XIA Wen-Shui

1.School of Food Science and Technology, Southern Yangtze University; 2.Huaiyin Institute of Technology

Online:2005-09-15 Published:2011-09-20

摘要/Abstract

摘要： 壳聚糖经氨基保护、与对乙酰氧基苯甲酰氯发生酯化、再水合肼去保护合成得到了对羟基苯甲酸壳聚糖酯。在适宜的反应条件下,对羟基苯甲酸壳聚糖酯酯化度可达130%、得率80%以上。产物经IR分析,酸与壳聚糖之间生成了酯,该酯溶解性略优于对羟基苯甲酸庚酯,而醇溶性显著提高;对大肠杆菌和金黄色葡萄球菌抗菌试验表明,该酯抗菌活性大于对羟基苯甲酸庚酯,更优于壳聚糖。

关键词: 对羟基苯甲酸酯, 抗菌活性, 表征

Abstract: After protection of amine group, chitosan reacted with 4-acetoxy-benzoate chloride to form a ester, and the ester was reacted with hydrazine hydrate to be deprotected, para-hydroxybenzoate chitosan ester was obtained. Under optimum reaction conditions, esterification degree of para-hydroxybenzoate chitosan ester was 130%, and yield reached 80%. IR spec- trum showed the ester bond was formed between para-hydroxybenzonic acid and chitosan. Water solubility of the ester was slightly better than heptyl para-hydroxybenzoate, but alcohol solubility was greatly improved. The antimicrobial activity for Staphyloccus aurueus and Escherichia coli was better than heptyl para-hydroxybenzoate and much better than chitosan.

Key words: para-hydroxybenzoate chitosan ester, antimicrobial activity, characterization

赵希荣, 夏文水. 对羟基苯甲酸壳聚糖酯的制备、表征和抗菌活性[J]. 食品科学, 2005, 26(9): 192-195.

ZHAO Xi-Rong, XIA Wen-Shui. Synthesis, Characterization and Antimicrobial Activity of Para-hydroxybenzoate Chitosan Ester[J]. FOOD SCIENCE, 2005, 26(9): 192-195.

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