食品科学 ›› 2006, Vol. 27 ›› Issue (10): 517-520.

• 营养卫生 • 上一篇    下一篇

柚皮提取物的降血脂和抑肿瘤作用

 张海德,  何继芹,  黄玉林   

  1. 华南热带农业大学理工学院
  • 出版日期:2006-10-15 发布日期:2011-11-16

Antitumor and Antilipemic Action of Pummelo(Citrus grandis L. Osbeck) Peel Extract

 ZHANG  Hai-De,   He-Ji-Qin,   Huang-Yu-Lin   

  1. College of Technology, South China University of Tropical Agriculture, Dianzhou 571737, China
  • Online:2006-10-15 Published:2011-11-16

摘要: 为了探讨柚皮提取物的生物活性,采用动物试验研究了柚皮抗氧化物质的降血脂和抑肿瘤作用。与高脂组相比,样品组能显著降低昆明种小白鼠血清胆固醇(TC)、血清甘油三酯(TG)和低密度脂蛋白胆固醇(LDL-C)的浓度,并相对升高高密度脂蛋白胆固醇(HDL-C)的浓度(p<0.05)。试验发现柚皮提取液对S180肉瘤具有抑制作用,抑瘤率为29.7%,与正常对照组比较,肿瘤对照组小鼠的胸腺明显缩小,平均湿重指数为1.2±0.4mg/kg,明显低于正常对照组(2.6±0.8mg/kg)(p<0.01)。而样品组小鼠胸腺指数(2.0±0.5mg/kg)明显高于肿瘤对照组(p<0.05)。结果表明,在一定的剂量下,柚皮提取液能降低高脂昆明种小白鼠血脂;对荷S180小鼠的肿瘤生长有抑制作用,并且能增强机体的免疫功能。

关键词: 柚, 提取物, 降血脂, 抑肿瘤

Abstract:  In order to study the bioactivity of extract from pummelo peel, the antilipemic action and antitumor capacity of the extract were studied by mice in vivo. The sample group of mice had significantly lower concentration of total cholesterol (TC), triglyceride (TG), and low density lipoprotein cholesterol (LDL-C) (p<0.05), significantly higher concentration of high density lipoprotein cholesterol (HDL-C) (p<0.05) in serum of mice than that of the high lipid control group. The rate of inhibiting S180 growth in sample group was 29.7%. The mean wet weight of thymus gland of tumor control group was 1.2± 0.4mg/kg, significantly lower than that of the normal control group which was 2.6±0.8mg/kg (p<0.01), and the mean wet weight of thymus gland of sample group was 2.0±0.5mg/kg, significantly higher than that of the tumor control group (p<0.05). It shown that the extract could decease the lipemia concentration of white Kunming mice, inhibit the growth of tumor S180 and improve the immunity ability of the mice.

Key words:  , pummelo; extract; antilipemic; antitumor;