食品科学 ›› 2011, Vol. 32 ›› Issue (13): 280-283.doi: 10.7506/spkx1002-6630-201113060

• 营养卫生 • 上一篇    下一篇

桑叶多糖对小鼠免疫调节作用的影响

侯瑞宏1,2,廖森泰1,*,刘凡1,邹宇晓1,邓媛媛1   

  1. 1.广东省农业科学院蚕业与农产品加工研究所 2.华南农业大学食品学院
  • 出版日期:2011-07-15 发布日期:2011-07-02
  • 基金资助:
    国家现代农业产业技术体系建设专项;国家公益性行业(农业)科研专项蚕桑项目(nkhyzx07-020-05); 广东省自然科学基金团队项目(9351064001000002);广东省科技计划项目(2008A030101001;2009A030100005)

Immunomodulatory Effect of Polysaccharides from Mulberry Leaves (PML) in Mice

HOU Rui-hong1,2,LIAO Sen-tai1,*,LIU Fan1,ZOU Yu-xiao1, DENG Yuan-yuan1   

  1. 1. Sericulture & Farm Produce Processing Research Institute, Guangdong Academy of Agricultural Sciences, Guangzhou 510610, China;2. College of Food Science, South China Agricultural University, Guangzhou 510642, China
  • Online:2011-07-15 Published:2011-07-02

摘要: 目的:研究桑叶多糖对正常小鼠免疫功能的调节作用。方法:桑叶多糖分别以125、250、500mg/(kg ·d)小鼠灌胃,空白对照组予以等量生理盐水,连续给药30d后,通过小鼠碳廓清实验、血清溶血素测定、脾淋巴细胞转化实验、脏器指数来观察桑叶多糖的免疫调节作用。结果:在125~500mg/(kg ·d)剂量范围内,桑叶多糖可显著提高小鼠碳廓清指数和血清溶血素水平及 ConA诱导的小鼠脾淋巴细胞转化能力; 低剂量组可显著提高小鼠胸腺指数。结论:桑叶多糖对正常小鼠具有一定的免疫增强作用。

关键词: 桑叶, 多糖, 免疫调节

Abstract: Objective: To explore the effect of polysaccharides from mulberry leaves (PML) on the immune function of mice. Methods: KM mice were administered with polysaccharides from mulberry leaves at the doses of 125, 250 mg/(kg ·d) and 500 mg/(kg ·d) by gavage for 30 consecutive days. The mice in blank group were administered with the same volume of saline. After the administration for 30 days, carbon clearance test, serum hemolysin determination, spleen lymphocyte transformation test and organ index (thymus and spleen) were investigated to explore the effect of PML on the immune function of mice. Results: At the investigated doses, PML could significantly improve carbon clearance capacity and spleen lymphocyte transformation capability induced by ConA. In low dose group, PML could significantly increase the thymus index. Conclusion: PML can enhance the immune function of mice.

Key words: mulberry leaves, polysaccharides, immunomodulation

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