新疆双峰驼乳对链脲佐菌素（STZ）诱导的糖尿病小鼠肝脏的保护作用

摘要/Abstract

摘要： 本实验以链脲佐菌素（Streptozotocin，STZ）诱导的1型糖尿病小鼠为模型，探讨了全驼乳组、驼脱脂组、驼酪蛋白组、驼乳清组和驼乳清蛋白组对糖尿病小鼠的影响，研究驼乳不同组分对1型糖尿病小鼠糖脂代谢，抗氧化，肝细胞形态和过氧化物酶体增殖物激活受体γ（Peroxisome proliferator-activated receptor γ，PPAR-γ）、固醇调节元件结合蛋白1c（Sterol regulatory element binding protein 1c，SREBP1c） mRNA表达的影响。结果表明：除驼酪蛋白以外的其余组分均能增加糖尿病小鼠体重、降低血糖、升高血清胰岛素水平、恢复血脂水平、提高肝脏抗氧化能力，并能减少肝组织的损伤。其中各项指标中,驼乳清组与模型组的变化最大且差异极显著（P<0.01）。经驼乳清组处理后的糖尿病小鼠肝PPAR-γ mRNA表达增加，SREBP1c mRNA表达下降。总的来说，驼乳清可有效改善STZ诱导的糖尿病小鼠糖脂代谢及肝组织损伤，其作用可能是上调PPAR-γ，下调SREBP1c mRNA表达有关。

关键词: 关键词：驼乳, 1型糖尿病, 肝损伤, 过氧化物酶体增殖物激活受体 γ（PPAR-γ）, 固醇调节元件结合蛋白1c （SREBP1c）

Abstract: In this research, streptozotocin (STZ)-induced type 1 diabetic mice were used as models to investigate the effects of whole camel milk, camel skim milk, camel casein, camel whey and camel whey protein on diabetic mice. The effects of different components of camel milk on glycolipid metabolism, antioxidant activity, hepatocyte morphology and peroxisome proliferator-activated receptor gamma (Peroxisome proliferator-activated receptor γ，PPAR-γ) and sterol regulatory element binding protein 1c (SREBP1c) on the expression of mRNA. The results showed that all the components except camel casein could increase the weight of diabetic mice, reduce blood sugar, increase serum insulin level, restore blood lipid level, improve liver antioxidant capacity, and reduce liver tissue damage. Among the indicators, camel whey and model had the greatest change and significant difference (p < 0.01). Camel whey could increase the expression of PPAR-gamma and reduce the expression of SREBP1c in liver of diabetic mice. As a result, Camel whey could effectively improve glycolipid metabolism and relief liver tissue damage in STZ-induced diabetic mice and its effect might be related to up-regulation of PPAR-gamma and down-regulation of SREBP1c gene expression.

Key words: Keywords: camel milk, type 1 diabetic, liver injury, Peroxisome proliferator-activated receptor γ （PPAR-γ), Sterol regulatory element binding protein 1c（SREBP1c）

中图分类号:

刘宸冯鑫欢豆智华安淑静刘梦娇侯志梅杨洁. 新疆双峰驼乳对链脲佐菌素（STZ）诱导的糖尿病小鼠肝脏的保护作用[J]. 食品科学, 0, (): 0-0.

liu chen. The protective effect of Xinjiang Bactrian camel milk on the liver of streptozotocin (STZ) - induced diabetic mice[J]. FOOD SCIENCE, 0, (): 0-0.

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