食品科学 ›› 2010, Vol. 31 ›› Issue (13): 307-311.doi: 10.7506/spkx1002-6630-201013070

• 专题论述 • 上一篇    下一篇

改善心血管健康的食源性生物活性肽构效关系研究进展

王春艳,田金强,王 强*   

  1. 中国农业科学院农产品加工研究所
  • 收稿日期:2009-12-03 修回日期:2010-03-22 出版日期:2010-07-01 发布日期:2010-12-29
  • 通讯作者: 王 强* E-mail:caaswangqiang@hotmail.com
  • 基金资助:

    新疆维吾尔自治区科技攻关重大专项(200831108)

Research Progress in Structure-activity Relationship of Food-derived Bioactive Peptides with Functions to Improve Cardiovascular Health

WANG Chun-yan,TIAN Jin-qiang,WANG Qiang*   

  1. Institute of Processing for Agriculture Products, Chinese Academy of Agricultural Sciences, Beijing 100193, China
  • Received:2009-12-03 Revised:2010-03-22 Online:2010-07-01 Published:2010-12-29
  • Contact: WANG Qiang* E-mail:caaswangqiang@hotmail.com

摘要:

食物源生物活性肽作为可改善健康状况的营养成分可由动植物食品在人体内消化或加工过程中产生,并表现出抗氧化、免疫调节、调节阿片样受体及抗菌、降压、降血脂、抗血栓等多种生理活性。通过调节和改善人体生理功能,生物活性肽可用于预防和治疗心血管疾病等慢性病。活性肽的来源、结构对其功能性质有重要影响。本文综述了与心血管健康有关的活性肽的构效关系研究进展,并对其研究前景进行展望。

关键词: 生物活性肽, 降压, 抗氧化, 降胆固醇, 抗血栓, 构效关系

Abstract:

Food-derived bioactive peptides with health-enhancing components can be released from a multitude of plant and animal proteins during gastrointestinal digestion or food processing. Bioactive peptides exhibit a series of functions such as antioxidant, immunomodulatory, opiate-like, antimicrobial, hypocholesterolemic, antithrombotic and antihypertensive functions. Through modulating and improving physiological functions, bioactive peptides can provide therapeutic applications for the prevention or treatment of chronic diseases. The sources and structures of these bioactive peptides have important effects on their functions. Structure-activity relationships of bioactive peptides related to cardiovascular health enhancement have been summarized, and future research and application of bioactive peptides have been proposed in this paper.

Key words: bioactive peptide, antihypertensive, antioxidant, hypocholesterolemic, antithrombotic, structure-activity relationship

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