食品科学 ›› 2011, Vol. 32 ›› Issue (15): 285-288.doi: 10.7506/spkx1002-6630-201115063

• 营养卫生 • 上一篇    下一篇

蚕蛹油α-亚麻酸对实验性高血脂大鼠的降脂作用

吴晓霞,李建科,刘迎利   

  1. 1. 陕西师范大学食品工程与营养科学学院
    2.陕西师范大学校医院
  • 出版日期:2011-08-15 发布日期:2011-07-26
  • 基金资助:
    陕西省“13115”科技创新工程重大科技专项(2009ZDKG-05)

Effect ofα-Linolenic Acid from Silkworm pupa Oil on Experimental hyperlipidemia in Rats

WU Xiao-xia1,LI Jian-ke1,*,LIU Ying-li2   

  1. (1. College of Food Engineering and Nutritional Science, Shaanxi Normal University, Xi an 710062, China; 2. Hospital of Shaanxi Normal University, Xi an 710062, China)
  • Online:2011-08-15 Published:2011-07-26

摘要: 目的:研究蚕蛹油(silkworm pupa oil,SPO)α-亚麻酸(α-linolenic acid)对实验性高血脂大鼠的预防和治疗作用。方法:建立远交群(sprague dawley,SD)大鼠高脂血症模型,预防性及治疗性给予蚕蛹油α-亚麻酸,测定并分析对大鼠血清甘油三酯(TG)、总胆固醇(TC)、高密度脂蛋白胆固醇(HDL-C)、载脂蛋白A-I(apolipoprotein A-I,Apo A-I)及脂蛋白酯酶(lipoprotein lipase,LPL)和肝脂酶(hepatic lipase,HL)活性的影响。结果:蚕蛹油α-亚麻酸具有显著降低实验性高血脂大鼠血清TC、TG,升高HDL-C、Apo A-I的作用,同时可以增强LPL及HL活性。结论:蚕蛹油α-亚麻酸具有显著的预防和治疗高脂血症的作用。

关键词: 蚕蛹油, 多不饱和脂肪酸, 血脂, 载脂蛋白, 脂蛋白酯酶

Abstract: Objective: To investigate the preventive and therapeutic effects of α-linolenic acid from silkworm pupa oil in hyperlipidemic rats. Methods: Hyperlipidemia in SD rats was induced by feeding high-fat diet. α-Linolenic acid from silkworm pupa oil was also fed to the model rats. The contents of serum triglyceride (TG), total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C) and apolipoprotein AI (Apo A-I) were determined, and the activities of lipoprotein lipase (LPL) and hepatic lipase (HL) were analyzed. Results: α-Linolenic acid from silkworm pupa oil could result in a significant decrease in the contents of TC and TG, and an increase in the contents of HDL-C and Apo A-I and the activities of LPL and HL in hyperlipidemia rat serum. Conclusion: α-Linolenic acid from silkworm pupa oil has significantly preventive and therapeutic effects in hyperlipidemia rats.

Key words: silkworm pupa oil, α-linolenic acid, blood lipids, apolipoprotein, lipoprotein lipase

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