食品科学
• 专题论述 • 上一篇 下一篇
光翠娥，江 波
出版日期:
发布日期:
GUANG Cui-e，JIANG Bo
Online:
Published:
摘要：
血管紧张素转化酶2(ACE2)是人类ACE的同系物，它通过肾素-血管紧张素系统(RAS)新的作用分支ACE2-血管紧张素-(1-7)-Mas受体(ACE2-Ang-(1-7)-Mas)轴反向调节经典的ACE-AngⅡ-AT1受体轴，不平衡若持续，会导致心血管、肾、肺和中枢神经系统的病理生理。目前已发现ACE2激动剂的类似物广泛存在于天然植物性原料中。
关键词: 血管紧张素转化酶2(ACE2), 激动剂, 氧杂蒽酮
Abstract:
Angiotensin converting enzyme 2 (ACE2) is a homologue of the human ACE. ACE2 counter-regulates the effects of the classical ACE-Ang Ⅱ-angiotensin Ⅱ type 1 receptor (AT1R) axis via the function of the novel axis ACE2- angiotensin-(1-7)-Mas receptor [ACE2-Ang-(1-7)-Mas] of the renin-angiotensin system (RAS). A chronic and sustained imbalance between both axes may lead to pathophysiology of the cardiovascular, renal, pulmonary and central nervous system. ACE2 agonist analogues are abundantly found in many natural plant resources.
Key words: angiotensin converting enzyme 2 (ACE2), analogues, xanthone
光翠娥，江 波. 一个新的RAS调节靶标——血管紧张素转化酶2[J]. 食品科学, doi: 10.7506/spkx1002-6630-201311073.
GUANG Cui-e，JIANG Bo. ACE2: a New Target for the Regulation of Renin-angiotensin System[J]. FOOD SCIENCE, doi: 10.7506/spkx1002-6630-201311073.
0 / / 推荐
导出引用管理器 EndNote|Ris|BibTeX
链接本文: https://www.spkx.net.cn/CN/10.7506/spkx1002-6630-201311073
https://www.spkx.net.cn/CN/Y2013/V34/I11/348
京公网安备 11010202009729号