北五味子藤茎总三萜对小鼠酒精性肝损伤的保护作用

doi:10.7506/spkx1002-6630-201315047

食品科学

北五味子藤茎总三萜对小鼠酒精性肝损伤的保护作用

孟宪军，邓静，朱力杰，李斌*

沈阳农业大学食品学院，辽宁沈阳 110866

出版日期:2013-08-15 发布日期:2013-09-03
通讯作者: 李斌
基金资助:
国家自然科学基金青年科学基金项目(31201325)；辽宁省教育厅科学研究一般项目(L2011109)

Protective Effect of Triterpenoid from Schisandra chinensis (Turcz) Baill Rattan against Alcoholic Liver Disease in Mice

MENG Xian-jun，DENG Jing，ZHU Li-jie，LI Bin*

College of Food Science, Shenyang Agricultural University, Shenyang 110866, China

Online:2013-08-15 Published:2013-09-03
Contact: LI Bin

摘要/Abstract

摘要：

目的：研究北五味子藤茎总三萜化合物(TFSCBR)对小鼠急性酒精性肝损伤的保护作用。方法：采用56°北京红星二锅头白酒建立急性酒精肝损伤模型。将60只昆明小鼠随机分为6组，每组10只，分别为正常对照组、模型对照组及TFSCBR高、中、低剂量组和齐墩果酸阳性对照组。每天灌胃1次，TFSCBR高、中、低剂量分别为50、30、10mg/(kg·d)，齐墩果酸阳性对照组剂量为30mg/(kg·d)，正常对照组、模型对照组灌胃等量生理盐水，实验4周后，通过脏器质量和体质量计算肝脏指数，测定小鼠血清中丙氨酸氨基转移酶(ALT)、天冬氨酸氨基转移酶(AST)的含量，测定肝组织中过氧化脂质降解产物丙二醛(MDA)、还原型谷胱甘肽(GSH)和超氧化物歧化酶(SOD)含量。结果：中剂量的TFSCBR能显著降低酒精性肝损伤所引起的ALT、AST活性，抑制MDA含量的升高(P＜0.01)，有效地拮抗肝脏中SOD的活性与GSH含量的降低(P＜0.01)。肝脏病理学改变减轻或逆转。结论：TFSCBR中剂量对酒精性肝损伤具有保护功能。

关键词: 北五味子总三萜, 小鼠, 酒精性肝损伤

Abstract:

Objective: To explore the protective effect of triterpene compounds from Schisandra chinensis (Turcz)
Baill rattan (TFSCBR) against acute alcohol liver injury in mice. Methods: Acute alcoholic liver injury model was
induced by 56% Beijing Red Star Erguotou liquor. Totally 60 Kunming mice were randomly divided into 6 groups
of 10 mice each: normal group, alcohol model group, oleanolic acid (positive control, 30 mg/(kg·d)) group, and triterpenoid
low, middle and high dose (10, 30 mg/(kg·d) and 50 mg/(kg·d)) groups. The normal group and alcohol model group were
administered with an equal volume of normal saline. After 4 weeks of administration, the levels of serum alanine transaminase
(ALT), aspartate transaminase (AST) and liver malondialdehyde (MDA), glutathione (GSH) and super oxid edismutase (SOD)
were assayed. Results: TFSCBR treatment at the dose of 30 mg/(kg·d) significantly reduced the elevation of AST, ALT
and MDA (P ＜ 0.01), and significantly inhibited the decrease of SOD activity and GSH level (P ＜ 0.01) in mice
suffering from liver injury. Furthermore, hepatic pathological changes were attenuated or even reversed. Conclusion:
TFSCBR treatment at the dose of 30 mg/(kg·d) has a significant hepatoprotective effect against alcohol-induced liver
injury in mice.

Key words: triterpenoid from Schisandra chinensis (Turcz) Baill rattan, mouse, alcohol-induced liver injury

中图分类号:

TS255.1

孟宪军，邓静，朱力杰，李斌*. 北五味子藤茎总三萜对小鼠酒精性肝损伤的保护作用[J]. 食品科学, doi: 10.7506/spkx1002-6630-201315047.

MENG Xian-jun，DENG Jing，ZHU Li-jie，LI Bin*. Protective Effect of Triterpenoid from Schisandra chinensis (Turcz) Baill Rattan against Alcoholic Liver Disease in Mice[J]. FOOD SCIENCE, doi: 10.7506/spkx1002-6630-201315047.

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北五味子藤茎总三萜对小鼠酒精性肝损伤的保护作用

Protective Effect of Triterpenoid from Schisandra chinensis (Turcz) Baill Rattan against Alcoholic Liver Disease in Mice

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