薛荔籽果胶改善辣椒素诱导的去势雌性大鼠肠道内环境的损伤

doi:10.7506/spkx1002-6630-201319060

食品科学

薛荔籽果胶改善辣椒素诱导的去势雌性大鼠肠道内环境的损伤

陆红佳，苏昕峰，唐艳，刘雄*

西南大学食品科学学院，重庆 400715

出版日期:2013-10-15 发布日期:2013-09-27
通讯作者: 刘雄
基金资助:
国家星火计划项目(2008GA811014)；教育部留学归国人员启动项目(教外司留[2010]1174)

Effect of Pectin from Ficus pumila L. Seeds on Capsaicin-Induced Intestinal Injury in Ovariectomized Rats

LU Hong-jia，SU Xin-feng，TANG Yan，LIU Xiong*

College of Food Science, Southwest University, Chongqing 400715, China

Online:2013-10-15 Published:2013-09-27
Contact: LIU Xiong

摘要/Abstract

摘要：

目的：探讨薛荔籽果胶对辣椒素引起去势雌性大鼠肠道内环境损伤的影响。方法：选用30只Wistar成年雌性大鼠随机分组为5组，其中1组大鼠进行伪切除手术作对照(Sham组)，另外4组大鼠做双侧卵巢切除(OVX)手术，基础饲料喂养恢复1周后，分为空白组、薛荔籽果胶组、辣椒素组和薛荔籽果胶＋辣椒素组，实验期28d后解剖，测定盲肠面积、盲肠内容物水分含量、pH值、短链脂肪酸和微生物等指标，结果表明：辣椒素可以显著降低OVX大鼠体质量、盲肠组织各项指标及盲肠内容物短链脂肪酸含量和有益菌数量(P＜0.05)，显著升高盲肠内容物游离氨含量、pH值及有害菌数量(P＜0.05)，而薛荔籽果胶的添加进一步降低OVX大鼠体质量，同时降低盲肠内容物游离氨含量和pH值，增加肠道中乳酸杆菌、双歧杆菌数量，减少大肠杆菌数量，这说明薛荔籽果胶的添加对辣椒素引起去势雌性大鼠的肠道损伤具有一定的改善作用。

关键词: 薛荔籽果胶, 辣椒素, 卵巢切除大鼠, 短链脂肪酸, 肠道菌群

Abstract:

Objective: To explore the effect of pectin from Ficus pumila L. seeds on capsaicin-induced intestinal injury
in ovariectomized rats. Methods: Thirty adult female Wistar rats were divided into five groups. One group was shamovariectomized
as control group. The other four groups were doubly ovariectomized and one week later assigned as model
control, capsaicin, Ficus pumila L. seed pectin, Ficus pumila L. seed pectin + capsaicin groups. All rats were sacrificed
after 28 days of feeding to assay the area of the cecum, the content of water, pH and short-chain acids in it and intestinal
microflora. Results: Feeding capsaicin could reduce body weight and cecum value in rats, the content of short-chain acids
and the amount of beneficial bacteria significantly (P ＜ 0.05), and increase free ammonia content and pH in the cecum, the
amount of harmful bacteria significantly (P ＜ 0.05). Ficus pumila L. seed pectin could reduce body weight, free ammonia
content and pH, and result in an increase in the populations of Lactobacillus and Bifidobacterium and synchronous decrease
in Enterobacter. This study demonstrates that pectin from Ficus pumila L. seeds can ameliorate capsaicin-induced intestinal
injury in ovariectomized rats.

Key words: Ficus pumila L.seeds pectin, capsaicin, ovariectomized rat, short-chain fatty acids, intestinal microflora

中图分类号:

TS201.4

陆红佳，苏昕峰，唐艳，刘雄*. 薛荔籽果胶改善辣椒素诱导的去势雌性大鼠肠道内环境的损伤[J]. 食品科学, doi: 10.7506/spkx1002-6630-201319060.

LU Hong-jia，SU Xin-feng，TANG Yan，LIU Xiong*. Effect of Pectin from Ficus pumila L. Seeds on Capsaicin-Induced Intestinal Injury in Ovariectomized Rats[J]. FOOD SCIENCE, doi: 10.7506/spkx1002-6630-201319060.

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薛荔籽果胶改善辣椒素诱导的去势雌性大鼠肠道内环境的损伤

Effect of Pectin from Ficus pumila L. Seeds on Capsaicin-Induced Intestinal Injury in Ovariectomized Rats

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