食品科学 ›› 2021, Vol. 42 ›› Issue (13): 319-325.doi: 10.7506/spkx1002-6630-20200605-072

• 专题论述 • 上一篇    下一篇

母乳低聚糖与婴儿肠道菌群相关性研究进展

袁慧芝,荀一萍,蒲晓璐,朱宏,王世杰   

  1. (1.河北科技大学食品与生物学院,河北 石家庄 050018;2.石家庄君乐宝乳业有限公司,河北 石家庄 050221)
  • 出版日期:2021-07-15 发布日期:2021-07-27
  • 基金资助:
    “十三五”国家重点研发计划重点专项(2018YFD0501606);河北省省级科技项目重大专项(19027143Z); 河北省重点研发计划项目(19222812D);石家庄市科学技术研究与发展计划项目(201170154A)

Progress in Understanding the Relationship between Human Milk Oligosaccharides and Infant Gut Microbiota

YUAN Huizhi, XUN Yiping, PU Xiaolu, ZHU Hong, WANG Shijie   

  1. (1. College of Food Science and Biology, Hebei University of Science and Technology, Shijiazhuang 050018, China; 2. Shijiazhuang Junlebao Dairy Co., Ltd., Shijiazhuang 050221, China)
  • Online:2021-07-15 Published:2021-07-27

摘要: 母乳中含有丰富的母乳低聚糖(human milk oligosaccharides,HMOs),可以刺激新生儿肠道中有益细菌的生长从而起到益生元的作用。目前我国允许添加到婴幼儿配方奶粉中的低聚糖在结构上与HMOs不同,因此,它们无法模拟HMOs的某些结构特异性效应。本文综述了HMOs的组成、结构以及在母乳中的含量,重点阐述了HMOs及其代谢产物与婴儿肠道微生物群间的关系,最后探讨了HMOs配方奶粉喂养对婴儿肠道菌群产生的有益作用,为推进HMOs在婴幼儿配方食品中的应用提供理论支持。

关键词: 母乳低聚糖;组成结构;婴儿;肠道菌群;相关性;代谢产物

Abstract: Breast milk is rich in human milk oligosaccharides (HMOs), which are prebiotics that can stimulate the growth of beneficial bacteria in the neonatal intestine. At present, the oligosaccharides allowed to be added to infant formula in China are structurally different from HMOs so that they cannot simulate some structure-specific effects of HMOs. This review describes the composition, structure and content of HMOs in breast milk, focusing on the relationship between HMOs as well as their metabolites and the infant intestinal microbiota. Finally, the beneficial effects of feeding infant formula with HMOs on the infant intestinal flora are discussed, which will provide theoretical support for promoting the application of HMOs in infant formula foods.

Key words: human milk oligosaccharides; compositional structure; infant; gut microbiome; correlation; metabolites

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