食品科学

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柠檬酸在产油酵母油脂积累过程中的中心作用

唐文佳1,张怀渊1,陈 卫1,2,宋元达1,*   

  1. 1.江南大学食品学院,江苏 无锡 214122;2.江南大学 食品科学与技术国家重点实验室,江苏 无锡 214122
  • 出版日期:2013-10-15 发布日期:2013-09-27
  • 通讯作者: 宋元达
  • 基金资助:

    国家自然科学基金面上项目(31171636;81071685)

The Central Role of Citrate in Lipid Accumulation in Oleaginous Yeasts

TANG Wen-jia1,ZHANG Huai-yuan1,CHEN Wei1,2,SONG Yuan-da1,*   

  1. 1. School of Food Science and Technology, Jiangnan University, Wuxi 214122, China;
    2. State Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi 214122, China
  • Online:2013-10-15 Published:2013-09-27
  • Contact: SONG Yuan-da

摘要:

产油酵母可以积累大量油脂,具有重要的应用价值,近年来,关于柠檬酸和脂质合成的关系的研究报道很多,研究发现产油酵母整个油脂积累的过程都需要柠檬酸的参与,油脂积累所需要的乙酰辅酶A主要由柠檬酸提供,柠檬酸在线粒体膜和细胞膜上的转运对产油酵母油脂含量的影响较大。细胞质和线粒体内的柠檬酸对油脂积累过程中的许多重要酶具有调节作用。柠檬酸是连接糖代谢与脂代谢的桥梁,在产油酵母油脂积累过程中起到中心作用。本文通过对柠檬酸在产油酵母油脂积累代谢的中心作用进行综述,以期为探究产油酵母油脂积累机制提供一定的参考。

关键词: 产油酵母, 油脂积累, 柠檬酸, 柠檬酸转运蛋白

Abstract:

Oleaginous yeasts are capable of accumulating large amount of lipids and show great potential for industrial
applications, which attracted the increasing research interests. In recent years, more researches have been carried out to
investigate the relationship between citrate metabolism and lipid biosynthesis. It is now believed that that citrate participates
in the metabolic process of lipid accumulation and provides acetyl-CoA for fatty acid biosynthesis in oleaginous yeasts.
The transporting behavior of citrate from mitochondria and cytoplasm affects the lipid content in oleaginous yeasts. Citrates
in cytoplasm and mitochondrial function as modulators of several key enzymes related to the metabolic process of lipid
accumulation in oleaginous yeasts. Citrate acts as a bridge between glycolysis and lipid biosynthesis, and plays a central role in
regulating lipid accumulation in oleaginous yeasts. In summary, the central role of citrate metabolism in lipid accumulation was
reviewed, which will provide useful references for exploring the mechanism of lipid accumulation in oleaginous yeasts.

Key words: oleaginous yeast, lipid accumulation, citrate, citrate transporter

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