食品科学

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D-柠檬烯抗癌机制的研究进展

黄巧娟,孙志高*,龙 勇,孙 谦   

  1. 西南大学柑桔研究所,重庆 400712
  • 出版日期:2015-04-15 发布日期:2015-05-05

Recent Progress in Research on Anticancer Mechanism of D-Limonene

HUANG Qiaojuan, SUN Zhigao*, LONG Yong, SUN Qian   

  1. Citrus Research Institute, Southwest University, Chongqing 400712, China
  • Online:2015-04-15 Published:2015-05-05

摘要:

D-柠檬烯是一种天然的单萜烯,广泛存在于柑橘、蔬菜及香料中,具有消炎、抑菌、抗肿瘤等多种功效。其中抗癌是D-柠檬烯的主要药理活性之一,其抗癌机制主要包括化学预防作用、抑制细胞周期与诱导细胞凋亡以及抑制肿瘤转移与侵袭等。由于D-柠檬烯具有来源广泛、安全性好、给药方便等优点,具有良好的开发前景和临床应用价值,亟待深入研究。

关键词: D-柠檬烯, 癌症, 抗癌机制, 细胞凋亡

Abstract:

D-Limonene, widely present in citrus, vegetables and spices, is a natural monoterpene. It plays an important
role in many physiological processes, such as reducing inflammation, minimizing bacterial growth, and inhibiting cancer
development. Anticancer effect is the major function of D-limonene by participating in chemical prevention, cell-cycle
inhibition, induction of apoptosis, and defense against cancer proliferation and invasiveness. D-Limonene has great prospects
for clinical application for its wide distribution, excellent safety, and convenient administration. Therefore, it is worthy of
further exploration.

Key words: D-limonene, cancer, anticancer mechanism, apoptosis

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