食品科学

• 营养卫生 • 上一篇    下一篇

吉林人参低聚肽对高脂血症大鼠的影响

李 迪,刘 睿,李 慧,陈启贺,张召锋,王军波*,李 勇*   

  1. 北京大学公共卫生学院营养与食品卫生学系,北京 100191
  • 出版日期:2017-03-15 发布日期:2017-03-28

Hypolipidemic Effect of Oligopeptide Derived from Panax ginseng Grown in Jilin Province on Rats with Hyperlipidemia

LI Di, LIU Rui, LI Hui, CHEN Qihe, ZHANG Zhaofeng, WANG Junbo*, LI Yong*   

  1. Department of Nutrition and Food Hygiene, School of Public Health, Peking University, Beijing 100191, China
  • Online:2017-03-15 Published:2017-03-28

摘要: 目的:观察吉林人参低聚肽(ginseng oligopeptides,GOP)对高脂血症模型大鼠是否具有降脂作用。方法:取SD大鼠108 只,设立9 个实验组:6 个GOP剂量组(0.062 5、0.125 0、0.250 0、0.500 0、1.000 0、2.000 0 g/kg)、1 个空白对照组、1 个乳清蛋白组(0.250 0 g/kg)和1 个模型对照组。空白对照组每日给予基础饲料,其余各组每日给予高脂饲料,2 周后各组继续给予相应饲料并连续灌胃30 d。结果:GOP各剂量组大鼠血清胆固醇、低密度脂蛋白胆固醇、高密度脂蛋白胆固醇、甘油三酯含量均无明显变化(P>0.05);GOP能够降低高脂血症大鼠血清和肝脏丙二醛含量(P<0.01),提高血清和肝脏超氧化物歧化酶、谷胱甘肽过氧化物酶活力(P<0.01),升高血清一氧化氮和一氧化氮合酶含量(P<0.01)。结论:GOP没有辅助降血脂作用,GOP可能具有抗动脉硬化作用。

关键词: 吉林人参低聚肽, SD大鼠, 高脂血症, 动脉粥样硬化

Abstract: Purpose: To investigate the effect of oligopeptide from Panax ginseng grown in Jilin province (GOP) on hyperlipidemic rats. Methods: Totally 108 specific pathogen free (SPF) male SD rats were randomly divided into 9 groups: normal control, model, whey protein group, and six GOP groups with different doses. The rats from the normal control group were fed a basal diet only. The rats from the rest groups were fed a high-fat diet for 2 weeks. Then, the rats in six GOP groups were gavaged with GOP at doses of 0.062 5, 0.125 0, 0.250 0, 0.500 0, 1.000 0 and 2.000 0 g/kg, respectively, those in the normal control and model groups with the same volume of distilled water, and those in the whey protein group with whey protein at a dose of 0.250 0 g/kg for 30 days. At the same time, all rats were provided with the corresponding diets uninterruptedly. Results: The TC, LDL-C, HDL-C and TG levels in serum had no significant change in rats from the GOP groups at each dose. The MDA level was significantly decreased and SOD and GSH-Px activities were significantly elevated in serum and liver tissue of rats from the GOP groups. Besides, serum NO and NOS levels were significantly elevated in the GOP groups. Conclusion: GOP does not has a hypolipidemic effect, but it may have an anti-atherosclerosis effect.

Key words: oligopeptide from Panax ginseng grown in Jilin province, SD rats, hypolipidemic, atherosclerosis

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