食品科学 ›› 2019, Vol. 40 ›› Issue (5): 295-302.doi: 10.7506/spkx1002-6630-20181013-105

• 专题论述 • 上一篇    下一篇

天然产物通过调控miRNA和自噬延缓阿尔茨海默病的研究进展

陈丹丹1,陈 宁2,*,寇现娟2,*   

  1. 1.武汉体育学院研究生院,湖北 武汉 430079;2.武汉体育学院健康科学学院,运动训练监控湖北省重点实验室,天久运动营养食品研发中心,湖北 武汉 430079
  • 出版日期:2019-03-15 发布日期:2019-04-02
  • 基金资助:
    国家自然科学基金青年科学基金项目(81601228);湖北省体育教育与健康促进学科群项目;湖北省高等学校优秀中青年科技创新团队项目(T201624)

Natural Products Alleviate Alzheimer’s Disease through Regulating miRNA and the Autophagy Signal Pathway

CHEN Dandan1, CHEN Ning2,*, KOU Xianjuan2,*   

  1. 1. Graduate School, Wuhan Sports University, Wuhan 430079, China; 2. Hubei Key Laboratory of Sport Training and Monitoring, Tianjiu Research and Development Center for Exercise Nutrition and Foods, College of Health Science, Wuhan Sports University, Wuhan 430079, China
  • Online:2019-03-15 Published:2019-04-02

摘要: 阿尔茨海默病(Alzheimer’s disease,AD)是一种与年龄增长密切相关的神经系统退行性疾病,发病后将严重影响老年人的健康生活,但AD的病理机制十分复杂,至今临床上常用的抗AD药物也只能改善中、轻度AD患者的症状,并不能预防、终止和逆转AD进程的发展。因此研究已逐渐转到能够将预防和治疗结合为一体的天然产物上,并且已有众多研究证实天然产物能够改善AD的两大病理特征——老年斑块和神经纤维缠结,而目前越来越多的研究发现了天然产物与AD相关的miRNA和自噬的关联。miRNA与自噬是目前AD研究的两大最新靶点,而随着自噬和miRNA在AD中的作用机制逐渐清晰,进一步证实了天然产物在AD防治方面发挥的重要作用。

关键词: 自噬, miRNA, 阿尔茨海默病, 天然产物

Abstract: Alzheimer’s disease (AD), an age-related neurodegenerative disease, can seriously affect the health of the elderly. Since the pathogenesis of AD is very complex, the commonly used drugs in clinical practice against AD can attenuate the symptoms of mild to moderate AD, but cannot prevent, terminate or reverse the progression of AD. Therefore, natural products that can prevent and treat AD have gained great attention, and the majority of studies have confirmed that natural products can improve two major pathological features of AD, senile plaques and neurofibrillary tangles. Recently, accumulating studies have demonstrated that natural products function to prevent and treat AD through regulating miRNA and autophagy, which will be beneficial for establishing novel and effective strategies for the prevention and treatment of AD in the future.

Key words: autophagy, miRNA, Alzheimer’s disease, natural products

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