食品科学 ›› 2021, Vol. 42 ›› Issue (9): 302-311.doi: 10.7506/spkx1002-6630-20200405-053

• 专题论述 • 上一篇    下一篇

茶叶预防紫外辐射应激损伤作用与机制研究进展

唐湘粤,陈颖,余鹏辉,鹿颜,龚雨顺   

  1. (湖南农业大学园艺学院,国家植物功能成分利用工程技术研究中心,茶学教育部重点实验室,湖南 长沙 410128)
  • 出版日期:2021-05-15 发布日期:2021-06-02
  • 基金资助:
    湖南省教育厅科研创新项目(18A101);湖南省研究生科研创新项目(CX2018B406)

Progress in Research on the Preventive Effect and Mechanism of Tea on Ultraviolet Radiation-Induced Oxidative Stress

TANG Xiangyue, CHEN Ying, YU Penghui, LU Yan, GONG Yushun   

  1. (National Research Center of Engineering Technology for Utilization Ingredients from Botanicals, Key Laboratory of Tea Science, Ministry of Education, College of Horticulture, Hunan Agricultural University, Changsha 410128, China)
  • Online:2021-05-15 Published:2021-06-02

摘要: 过量紫外辐射会使细胞处于应激状态,导致活性氧过量积累和DNA损伤,进而破坏细胞内稳态平衡。茶叶具有预防紫外应激损伤及诱导相关疾病的作用,茶叶中主要功能成分茶多酚等可以直接吸收紫外辐射,并且能够结合机体体内特异性靶点协助调控代谢。本文综述了茶叶通过维持细胞内稳态平衡预防紫外应激损伤的相关研究,阐述了茶叶对紫外辐射应激损伤的修复机制,即增强DNA损伤修复、抑制炎性小体激活、维持炎症因子动态平衡以及调控应激性睡眠;此外对茶叶抗紫外辐射损伤的研究方向进行了展望。

关键词: 茶叶;细胞内稳态;紫外辐射;DNA损伤;炎性小体

Abstract: Excessive ultraviolet radiation can put cells under stress, resulting in excessive accumulation of reactive oxygen species and DNA damage, and consequently disturbing the intracellular homeostasis. Tea is known to have a preventive effect against ultraviolet radiation-induced damage and related diseases. As a major class of function ingredients in tea, tea polyphenols are able to directly absorb ultraviolet radiation and assist metabolic regulation by binding to the specific targets in the body. In this paper, we review recent studies on how tea can prevent ultraviolet radiation-induced damage by maintaining the intracellular homeostasis. The mechanisms of action of tea in repairing ultraviolet radiation-induced damage are also described, including enhancing the repairing of DNA damage, inhibiting the activation of inflammasomes, maintaining the dynamic balance of inflammatory factors, and regulating the repairing mechanism of stress-induced sleep damage. Moreover, future directions for research on the preventive effect of tea on ultraviolet radiation-induced damage are discussed.

Key words: tea; intracellular homeostasis; ultraviolet radiation; DNA damage; inflammasome

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