食品科学 ›› 2021, Vol. 42 ›› Issue (15): 346-355.doi: 10.7506/spkx1002-6630-20200428-368

• 专题论述 • 上一篇    下一篇

生物活性硒肽的研究进展

贾蕾,向极钎,殷红清,何慧,侯焘   

  1. (1.华中农业大学食品科学技术学院,湖北 武汉 430070;2.恩施土家族苗族自治州农业科学院,湖北 恩施 445000)
  • 发布日期:2021-08-27

Progress in Bioactive Selenium-Containing Peptides

JIA Lei, XIANG Jiqian, YIN Hongqing, HE Hui, HOU Tao   

  1. (1. College of Food Science and Technology, Huazhong Agricultural University, Wuhan 430070, China;2. Enshi Tujia & Miao Autonomous Prefecture Academy of Agricultural Sciences, Enshi 445000, China)
  • Published:2021-08-27

摘要: 硒是人体生长代谢必需的微量元素,而生物活性硒肽是补充有机硒的重要来源。随着对硒及其衍生物相关营养学价值探究的深入,硒肽除却其基础营养价值外的多种潜在健康益处也逐渐被发现。硒肽多从富硒植物中分离,但由于硒资源分布不均和现有生产技术限制,无法满足工业化生产。此外,当前对硒肽的结构尚没有系统性的探究策略,无法为硒肽的构效关系提供更多证据,而蛋白质组学、肽组学等技术的发展对于进一步认识硒肽具有积极作用。本文根据近年来国内外的研究,概述了硒的生物学功能及其代谢途径,并对生物活性硒肽的来源、制备、生物活性、结构特征进行综述,同时对硒肽与不含硒同源肽的生物活性的比较研究进行综述,以期为生物活性硒肽的研究提供理论指导。

关键词: 硒;生物活性硒肽;代谢;生理功能

Abstract: Selenium is an essential trace element for human growth and metabolism, and bioactive selenium-containing peptides are an important organic source of selenium. Besides the nutritional value of selenium and its derivatives, various potential health benefits of selenium-containing peptides have been gradually discovered. While selenium-containing peptides are mostly isolated from selenium-enriched plants, selenium resources are unevenly distributed and the existing production technologies have some limitations, making it impossible to meet the industrial production requirements. Moreover, the structure of selenium-containing peptides has not yet been systematically explored so that there is no sufficient evidence to support the structure-activity relationship of selenium-containing peptides. The development of proteomics and peptidomics helps researchers better understand selenium-containing peptides. Based on recent studies in China and abroad, this article summarizes the biological functions of selenium and its metabolic pathways, as well as the sources, preparation methods, biological activities and structural characteristics of bioactive Se-containing peptides. A comparison of the biological activities of Se-containing peptides and their selenium-free counterparts is presented as well. We expect that this review will theoretically guide further research and development of bioactive Se-containing peptides.

Key words: selenium; bioactive selenium-containing peptides; metabolism; physiological function

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