食品科学 ›› 2021, Vol. 42 ›› Issue (11): 341-348.doi: 10.7506/spkx1002-6630-20200517-196

• 专题论述 • 上一篇    下一篇

利用纳米载体口服递送生物活性肽的研究进展

郝晓丽,吉日木图,何静   

  1. (1.内蒙古农业大学 乳品生物技术与工程教育部重点实验室,内蒙古 呼和浩特 010018;2.内蒙古骆驼研究院,内蒙古 巴丹吉林 737300)
  • 出版日期:2021-06-15 发布日期:2021-06-29
  • 基金资助:
    内蒙古自治区科技创新引导项目(KCMS2018048);内蒙古自治区科技重大项目;内蒙古自然科学基金项目(2018BS03017); 内蒙古农业大学“双一流”学科创新团队建设人才培育项目(NDSC2018-14); 内蒙古农业大学高层次人才引进科研启动项目(NDYB2017-28;NDYB2018-48); 教育援外项目“丝路1+1”科研合作项目

Recent Progress of Nanocarriers for the Oral Delivery of Bioactive Peptides

HAO Xiaoli, Jirimutu, HE Jing   

  1. (1. Key Laboratory of Dairy Biotechnology and Bioengineering, Ministry of Education, Inner Mongolia Agricultural University, Hohhot 010018, China; 2. Inner Mongolia Institute of Camel Research, Badanjilin 737300, China)
  • Online:2021-06-15 Published:2021-06-29

摘要: 生物活性肽因具有高生理活性和生物相容性已被用于预防或治疗各种疾病。纳米载体在生物活性肽的稳定性方面发挥重要作用,对其穿过胃肠道时提供了强有力的保护作用。口服给药的方式往往会很大程度地降低生物活性肽的生物利用度,制备纳米颗粒作为生物活性肽的口服给药递送系统旨在提高生物活性肽的生物利用度,从而提高治疗的靶向性。因此,本文综述了生物活性肽口服纳米载体给药系统的研究现状,重点介绍了生物活性肽口服给药递送的条件、多功能给药递送系统及其应用,旨在为生物活性肽的最大化利用提供参考。

关键词: 生物活性肽;口服给药;纳米载体;递送系统

Abstract: Bioactive peptides have been used to prevent or treat various diseases because of their high physiological activity and biocompatibility. Nanocarriers play an important role in the stabilization of bioactive peptides and can provide strong protection for bioactive peptides passing through the gastrointestinal tract. The bioavailability of bioactive peptides is often greatly reduced when they are orally administered. Nanoparticles have been prepared as an oral delivery system to enhance the bioavailability of bioactive peptides and thus improve therapeutic targeting. Accordingly, this article reviews the current status of studies on nanocarrier systems for the oral delivery of bioactive peptides with focuses on the conditions of oral delivery as well as various multifunctional delivery systems and their applications, aiming to provide a reference for maximizing the utilization of bioactive peptides.

Key words: bioactive peptides; oral administration; nanocarriers; delivery systems

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