食品科学 ›› 2021, Vol. 42 ›› Issue (21): 213-222.doi: 10.7506/spkx1002-6630-20200605-069

• 专题论述 • 上一篇    下一篇

黄烷-3-醇类化合物在体内的吸收、代谢特征与机制研究进展

刘若男,陈婉冰,晏芳芳,刘敏,鲁群,杨宏,刘睿   

  1. (1.华中农业大学食品科学与技术学院,环境食品学教育部重点实验室,湖北 武汉 430070;2.武汉市蜂产品质量控制工程技术研究中心,湖北 武汉 430000;3.农业农村部华中都市农业重点实验室,湖北 武汉 430000)
  • 出版日期:2021-11-15 发布日期:2021-11-23
  • 基金资助:
    国家自然科学基金面上项目(31671962);中央高校基本科研业务费专项资金项目(2662019PY034)

Recent Progress in Understanding the Characteristics and Mechanisms of Flavan-3-ols Absorption and Metabolism in Humans

LIU Ruonan, CHEN Wanbing, YAN Fangfang, LIU Min, LU Qun, YANG Hong, LIU Rui   

  1. (1. Key Laboratory of Environment Correlative Dietology, Ministry of Education, College of Food Science and Technology, Huazhong Agricultural University, Wuhan 430000, China; 2. Wuhan Engineering Research Center of Bee Products on Quality and Safety Control, Wuhan 430000, China; 3. Key Laboratory of Urban Agriculture in Central China, Ministry of Agriculture and Rural Affairs, Wuhan 430000, China)
  • Online:2021-11-15 Published:2021-11-23

摘要: 黄烷-3-醇类化合物是人类饮食中含量最丰富的膳食多酚之一,近年来,黄烷-3-醇类化合物备受关注,这主要是因为许多研究发现其与很多慢性疾病风险的降低和代谢综合征的缓解密切相关,但黄烷-3-醇类化合物在体内发挥的作用一定程度上取决于其被摄入后的吸收和代谢,尤其是肠道微生物的分解代谢。因此,本文将重点探讨黄烷-3-醇类化合物的吸收、代谢及其生物转化的途径,有助于揭示其在体内的生物学作用。

关键词: 黄烷-3-醇类化合物;吸收;肠道微生物;代谢机制

Abstract: Flavan-3-ols are one of the most abundant classes of dietary polyphenols in the human diet. In recent years, flavan-3-ols have attracted much attention because many studies have found that they are associated with reduced risks of many chronic diseases and alleviation of metabolic syndromes. However, the role of flavan-3-ols in the body depends to a certain extent on their absorption and metabolism after being ingested, especially their catabolism by intestinal microbes. In this context, this article focuses on reviewing the signaling pathways related to the absorption, metabolism and biotransformation of flavan-3-ols, which will be helpful for understanding their biological effects in the body.

Key words: flavan-3-ols; absorption; intestinal microbes; metabolic mechanism

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