食品科学 ›› 2022, Vol. 43 ›› Issue (17): 372-379.doi: 10.7506/spkx1002-6630-20210422-323

• 专题论述 • 上一篇    下一篇

乳铁蛋白调控脂肪细胞发育代谢的研究进展

安芹,汪雄,王文利,程智美,戴蕴平,张雅丽   

  1. (1.中国农业大学食品科学与营养工程学院,北京 100083;2.中国农业大学生物学院,北京 100083)
  • 出版日期:2022-09-15 发布日期:2022-09-28
  • 基金资助:
    农业农村部转基因重大专项(2018ZX08007001)

Recent Progress in Research on the Role of Lactoferrin in Regulating the Development and Metabolism of Adipocytes

AN Qin, WANG Xiong, WANG Wenli, CHENG Zhimei, DAI Yunping, ZHANG Yali   

  1. (1. College of Food Science and Nutritional Engineering, China Agricultural University, Beijing 100083, China; 2. College of Biological Sciences, China Agricultural University, Beijing 100083, China)
  • Online:2022-09-15 Published:2022-09-28

摘要: 肥胖是最严重的公共健康问题之一,而脂肪细胞的发育代谢与肥胖密切相关。乳铁蛋白作为一种多功能糖蛋白,具有多种生理活性,能够调节脂肪细胞的增殖分化、脂质代谢相关基因的表达以及脂肪细胞因子和炎症因子的表达,从而通过不同途径调控脂肪细胞的发育及代谢。本文综述了近年来乳铁蛋白调控脂肪细胞生理及其作用机制的研究进展,并提出了乳铁蛋白调控脂肪细胞发育代谢的未来研究方向和重点,为乳铁蛋白功能的深入研究以及产业应用提供参考。

关键词: 乳铁蛋白;脂肪细胞;脂质分解;脂肪合成

Abstract: Obesity is one of the most serious public health problems, and the development and metabolism of adipocytes are closely related to obesity. As a multifunctional glycoprotein, lactoferrin has a variety of physiological activities and can regulate the development and metabolism of adipocytes by regulating their proliferation and differentiation, the expression levels of lipid metabolism-related genes, and the expressions of adipocytes and inflammatory factors. This article reviews recent progress in research on the role of lactoferrin in regulating the physiology of adipocytes and the underlying mechanism, and proposes future research directions and focuses on the role of lactoferrin in regulating the development and metabolism of adipocytes. It is anticipated that this paper will provide a basis for further research on the functions of lactoferrin and its industrial applications.

Key words: lactoferrin; adipocyte; lipolysis; adipogenesis

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