食品科学 ›› 2021, Vol. 42 ›› Issue (23): 1-10.doi: 10.7506/spkx1002-6630-20210729-347

• 专家约稿 •    下一篇

经口给予透明质酸的生理功能及其作用机制研究进展

王钊,徐康,王方,郭彦南   

  1. (1.清华大学药学院,北京 100084;2.首都医科大学基础医学院,北京 100069;3.北京协和医院临床营养科,北京 100006)
  • 出版日期:2021-12-15 发布日期:2021-12-29
  • 基金资助:
    “十三五”国家重点研发计划重点专项(2018YFD0400204;2018YFC2000304)

Progress in Research on Physiological Function and Mechanism of Oral Hyaluronic Acid

WANG Zhao, XU Kang, WANG Fang, GUO Yannan   

  1. (1. School of Pharmaceutical Sciences, Tsinghua University, Beijing 100084, China; 2. School of Basic Medical Sciences, Capital Medical University, Beijing 100069, China; 3. Department of Clinical Nutrition, Peking Union Medical College Hospital, Beijing 100006, China)
  • Online:2021-12-15 Published:2021-12-29

摘要: 透明质酸(hyaluronic acid,HA)广泛存在于人体各个组织中,具有保湿、润滑等多种生理功能,并且参与到伤口愈合、炎症反应、组织修复等多个生物过程中。HA作为重要的医疗和美容材料,已被广泛应用于医药和化妆用品。2021年1月7日,国家卫生健康委员会发文,批准透明质酸钠为“新食品原料”,可应用于普通食品添加。口服作为最理想和经济、方便的给药方式,具有更高的使用依从性。本文综述了目前已发表的经口给予HA相关代表性研究成果,主要关注其在体内的吸收、分布和代谢途径,以及其对于不同组织、器官的保护功能,并结合药理、毒理研究为新型口服HA制剂的开发和应用提供科学依据,同时提高大众对于口服HA的正确认知。

关键词: 透明质酸;口服;人体健康

Abstract: Hyaluronic acid (HA) is widely found in various tissues of the human body and has various physiological functions such as moisturizing and lubricating effects, and it is involved in various biological processes such as wound healing, inflammatory response, and tissue repair. As an important medical and cosmetic material, HA has been widely used in medicine and cosmetic products. On January 7, 2021, the National Health Commission of China issued a document approving sodium hyaluronate as a “new food ingredient” that can be added in common foods. Oral administration is the most desirable, economical and convenient way of drug delivery, and there is high compliance with it. In this paper, we review representative published research findings on oral HA, with focuses on its absorption, distribution and metabolic pathways in the body, as well as its protective functions on different tissues and organs, which when combined with pharmacological and toxicological studies may provide a scientific basis for the development and application of oral HA formulations and provide improved knowledge of oral HA.

Key words: hyaluronic acid; oral; human health

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