食品科学 ›› 2024, Vol. 45 ›› Issue (4): 344-351.doi: 10.7506/spkx1002-6630-20230303-034

• 专题论述 • 上一篇    下一篇

中链脂肪酸在疾病辅助治疗中的应用及作用机制研究进展

贾惜文,徐嘉杰,梁雪岩,张慧,林昊,丁凯丽,何颖慧,刘烙阳,韩鲁佳,肖卫华   

  1. (1.中国农业大学工学院,北京 100083;2.宁波大学海洋学院,浙江 宁波 315211)
  • 出版日期:2024-02-25 发布日期:2024-03-11
  • 基金资助:
    现代农业产业技术体系建设专项(CARS36);中央高校基本科研业务费专项(15053349); 中药药渣高值化利用技术-横向项目(202105510711226)

Research Progress on the Application and Mechanism of Medium-Chain Fatty Acids in Adjuvant Therapy of Diseases

JIA Xiwen, XU Jiajie, LIANG Xueyan, ZHANG Hui, LIN Hao, DING Kaili, HE Yinghui, LIU Luoyang, HAN Lujia, XIAO Weihua   

  1. (1. College of Engineering, China Agricultural University, Beijing 100083, China; 2. School of Marine Sciences, Ningbo University, Ningbo 315211, China)
  • Online:2024-02-25 Published:2024-03-11

摘要: 随着消费水平和健康意识的逐渐提高,消费者对于功能性食品的需求不断增加。中链脂肪酸作为一种重要的膳食脂肪,因其具有独特的运输系统,在体内迅速代谢的同时可以产生较高的能量,成为高价值的功能性食品。本文在介绍中链脂肪酸类型和结构的基础上,详细阐述其在人体内的代谢途径;同时,总结归纳中链脂肪酸在不同疾病辅助治疗方面的研究案例;此外,重点概述中链脂肪酸在阿尔茨海默症、癫痫、癌症、糖尿病和肥胖等疾病辅助治疗中发挥的积极作用,并明晰其作用机制。最后对中链脂肪酸未来发展前景进行总结展望,以期为中链脂肪酸在食品及医药领域的高效应用及推广提供理论参考。

关键词: 中链脂肪酸;结构;代谢;健康;疾病辅助治疗

Abstract: As people’s consumption levels and health awareness have risen, the consumer demand for functional foods is steadily increasing. Medium-chain fatty acids (MCFAs), an important class of dietary fatty acids, have been regarded as high-value functional foods due to their unique transportation system and the fact that they can be metabolized rapidly in the body while producing high energy. Beginning with an overview of the types and structures of MCFAs, this paper goes on to elaborate the metabolic pathway of MCFAs in the human body and then summarize recent research on MCFAs in the adjuvant treatment of different diseases. This article focuses on the positive role of MCFAs in the adjuvant treatment of Alzheimer’s disease, epilepsy, cancer, diabetes, obesity, and other diseases, and expounds their action mechanism. Finally, an outlook on the future development of MCFAs is given. Overall, this review provides a theoretical basis for promoting the application of MCFAs in the fields of food and medicine.

Key words: medium-chain fatty acids; structure; metabolism; health; adjuvant disease treatment

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