石榴籽油对实验性高脂血症大鼠血脂及脂质过氧化的影响

食品科学 ›› 2007, Vol. 28 ›› Issue (2): 309-312.

石榴籽油对实验性高脂血症大鼠血脂及脂质过氧化的影响

李文敏, 敖明章, 汪俊汉, 余龙江, 张永忠, 万军梅

湖北职业技术学院医学院；华中科技大学生命科学与技术学院；华中科技大学医院检验科；华中科技大学生命科学与技术学院湖北孝感432100；湖北武汉430074；

出版日期:2007-02-15 发布日期:2011-12-31

Adjustment Effects of Seed Oil of Punica gramatum L. on Blood-lipid and Lipid-Hyperoxidation in Hyperlipidemia Rats

LI Wen-Min, AO Ming-Zhang, WANG Jun-Han, YU Long-Jiang, ZHANG Yong-Zhong, WAN Jun-Mei

1.Medical College, Hubei College of Vocation Technology, Xiaogan 432100, China; 2.College of Life Science and Techology, Huazhong University of Science and Technology, Wuhan 430074, China; 3.Check Bureau, Hospital of Huazhong University of Science and Technology, Wuhan 430074, China

Online:2007-02-15 Published:2011-12-31

摘要/Abstract

摘要： 目的:研究石榴籽油对高脂血症和脂质过氧化的调节作用。方法:50只雌性Wistar大鼠按体重均衡随机分为5组:空白对照组,模型对照组,石榴籽油高、低剂量组,辛伐他汀组,除空白对照组饲喂普通饲料外,其余各组饲喂高脂饲料并进行干预实验比较。结果:12w后,血清与肝脏TC、TG、MDA、LDL-C、AI等指标,高脂模型组均显著高于空白对照组(p<0.05或p<0.01),而HDL-C/TC、SOD活力均下降(p<0.05或p<0.01);石榴籽油小剂量组血清与肝脏TC、TG、MDA、血清LDL-C、AI等指标均显著低于高脂模型组(p<0.05或p<0.01),而HDL-C/TC、SOD活力均升高(p<0.05或p<0.01)。结论:石榴籽油对大鼠的高脂血症和动脉硬化的形成有明显的抑制作用。

关键词: 石榴籽油, 高脂血症大鼠, 脂质过氧化, 预防

Abstract: Objective: To study the adjustment effects of seed oil of Punica gramatum L. on blood-lipid and lipid-hyperoxidation in hyperlipidemia rats. Method: 50 female Wistar rats were divided randomly into 5 groups by body weight: control group, hyperlipidemia model group, seed oil of Punica gramatum L. high and low dose group and simvastatin group. The rats were fed with high-lipid foodstuff except control group, so the intervention tests were carried out. Results: After twelve weeks, the contents of serum and hepar total cholesterol(TC), triglyceride(TG), low-density lipoprotein cholesterol(LDL-C), arteriosclerosis index (AI) and malondialdehyde(MDA) of hyperlipidemia model group were all higher than the control group (p<0.05 or p<0.01), but high density lipoprotein ratio to total cholesterol (HDL-C/TC) and superoxide dismutase (SOD) activities were lower than the control group(p<0.05 or p<0.01). The contents of serum and hepar total cholesterol(TC), triglyceride(TG), low-density lipoprotein cholesterol(LDL-C), arteriosclerosis index(AI), malondialdehyde(MDA) in Punica gramatum L. low dose seed oil group were all lower than the hyperlipidemia model group (p<0.05 or p<0.01), but the high density lipoprotein ratio total cholesterol (HDL-C/TC) and superoxide dismutase(SOD) activities were higher than the control hyperlipidemia model group (p<0.05 or p<0.01). Conclusion: Seed oil of Punica gramatum L. has significant effects on controlling hyperlipidemia and atherosclerosisi n rats.

Key words: seed oil of Punica gramatum L., hyperlipidemia rat, lipid peroxidation, prevention

李文敏, 敖明章, 汪俊汉, 余龙江, 张永忠, 万军梅. 石榴籽油对实验性高脂血症大鼠血脂及脂质过氧化的影响[J]. 食品科学, 2007, 28(2): 309-312.

LI Wen-Min, AO Ming-Zhang, WANG Jun-Han, YU Long-Jiang, ZHANG Yong-Zhong, WAN Jun-Mei. Adjustment Effects of Seed Oil of Punica gramatum L. on Blood-lipid and Lipid-Hyperoxidation in Hyperlipidemia Rats[J]. FOOD SCIENCE, 2007, 28(2): 309-312.

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